APH-1 Antibody | EMD Millipore AB9214 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APH-1 Antibody

catalog :

AB9214

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 3e	Li J, Chiu J, Ramanjulu M, Blass B, Pratico D. A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles. Mol Neurodegener. 2020;15:1 pubmed publisher
western blot; mouse; fig 3d	Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
	Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher

product information

Catalog Number :

AB9214

Subcategory :

Neuroscience

Product Name :

Anti-APH-1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96BI3

Host Name :

Rabbit

Antigen :

APH-1

Conjugate :

Serum

Product Description :

Anti-APH-1 Antibody

Cross Reactivity :

Mouse

Background :

The processing of the type 1 transmembrane protein beta-amyloid precursor protein (APP) by gamma secretase is thought to be a key event needed for the deposition of the beta-amyloid peptide in senile plaques found in Alzheimer's disease. The proteolytic activity of the gamma secretase cleaves the transmembrane domain of APP and releases the beta-amyloid peptide. Early or aberrant gamma-secretase cleavage of APP underlies the majority of early onset, familial Alzheimer's disease. {Guo, M et al (2003) Hum Mol Genet. 12(20):2669-78}. The gamma secretase consists of complex of four membrane associated proteins including presenilin, nicastrin, Aph-1 and Pen-2 {Gu, Y et al (2003) J Biol. Chem. 278(9):7374-7380; Kimberly, WT et al (2003) PNAS, USA 100(11):6382-6387}. It is believed that Aph-1 is a membrane protein that directly associates with presenilin and nicastrin within the gamma-secretase protein complex and stabilizes the presenilin within the complex, and allows the for proteolytic processing of presenilin and activation of the gamma-secretase activity{Takasugi, N et al (2003) Nature 422(6930):438-441}.

Immunogen :

Synthetic peptide from hAPH-1a

Specificity :

APH-1.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.