MMP-15 Antibody | EMD Millipore AB855 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-15 Antibody

catalog :

AB855

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

AB855

Subcategory :

Cell Structure

Product Name :

Anti-MMP-15 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P51511

Host Name :

Rabbit

Antigen :

MMP-15

Conjugate :

Purified

Product Description :

Anti-MMP-15 Antibody

Cross Reactivity :

Human;Mouse

ALT Names :

MT2-MMP

Immunogen :

A synthetic peptide from the mouse MMP-15/MT2-MMP protein.

Specificity :

AB855 recognizes 62-68 kDa forms of a protein identified as MT2-MMP or MMP15. MMps are a group of enzymes involved in matrix degradation. To date there are sixteen members reported to belong to the family of matrix metalloproteinases. Of these sixteen proteins ten exist in soluble form whereas MT-MMPs exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastsis. CELLULAR LOCALIZATION: Cell Membrane

Package Size :

100 µg

Uses :

Immunohistochemistry (Paraffin)

Storage :

Store vial at 4 C. When stored at 2-8 C, this antibody is stable for 12 months.