Vinculin Antibody | EMD Millipore AB6039 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Vinculin Antibody

catalog :

AB6039

quantity :

50 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 3e	PÃ©rez CaÃ±amÃ¡s A, BenvegnÃ¹ S, Rueda C, RÃ¡bano A, SatrÃºstegui J, Ledesma M. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017;22:711-723 pubmed publisher
	Biancur D, Paulo J, Małachowska B, Quiles Del Rey M, Sousa C, Wang X, et al. Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism. Nat Commun. 2017;8:15965 pubmed publisher
	Johnson R, Finger E, Olcina M, Vilalta M, Aguilera T, Miao Y, et al. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016;18:1078-1089 pubmed publisher

product information

Catalog Number :

AB6039

Subcategory :

Cell Structure

Product Name :

Anti-Vinculin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P18206

Host Name :

Rabbit

Antigen :

Vinculin

Conjugate :

Affinity Purified

Product Description :

Anti-Vinculin Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

Cell spreading and movement occur though the process of binding of cell surface integrin receptors to extracellular matrix adhesion molecules. In mammalian cells, vinculin is a membrane-cytoskeletal protein in focal adhesion plaques that is involved in linkage of integrin adhesion molecules to the actin cytoskeleton. More specifically, vinculin binds to talin at its N-terminus, which, in turn, binds to beta integrins. At its C-terminus, vinculin binds to actin, phospholipids, and paxillin-forming homodimers. The binding complex of vinculin to talin and actin serves to anchor actin filaments to the membrane, (Ezzell, 1997). Vinculin's ability to interact with integrins at the focal adhesion appears to be critical for control of cytoskeletal mechanics, cell spreading, and lamellipodia formation. Thus, vinculin appears to play a key role in shape control based on its ability to modulate focal adhesion structure and function.

ALT Names :

Metavinculin

Immunogen :

KLH-conjugated synthetic peptide corresponding to an internal domain of human Vinculin.

Specificity :

The antibody recognizes an internal domain of human vinculin.

Package Size :

50 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt