F-actin-capping protein subunit beta Antibody | EMD Millipore AB6017 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

F-actin-capping protein subunit beta Antibody

catalog :

AB6017

quantity :

50 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunocytochemistry

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:500; loading ...; fig 7e	Spence E, Dube S, Uezu A, Locke M, Soderblom E, Soderling S. In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation. Nat Commun. 2019;10:386 pubmed publisher
western blot; rat; fig 5c	Lin Y, Warren C, Li J, McKinsey T, Russell B. Myofibril growth during cardiac hypertrophy is regulated through dual phosphorylation and acetylation of the actin capping protein CapZ. Cell Signal. 2016;28:1015-24 pubmed publisher
	Barger S, Reilly N, Shutova M, Li Q, Maiuri P, Heddleston J, et al. Membrane-cytoskeletal crosstalk mediated by myosin-I regulates adhesion turnover during phagocytosis. Nat Commun. 2019;10:1249 pubmed publisher
	Avenarius M, Krey J, Dumont R, Morgan C, Benson C, Vijayakumar S, et al. Heterodimeric capping protein is required for stereocilia length and width regulation. J Cell Biol. 2017;216:3861-3881 pubmed publisher

product information

Catalog Number :

AB6017

Subcategory :

Cell Structure

Product Name :

Anti-F-actin-capping protein subunit beta Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P47756

Host Name :

Rabbit

Antigen :

F-actin-capping protein subunit beta

Conjugate :

Purified

Product Description :

Anti-F-actin-capping protein subunit beta Antibody

Cross Reactivity :

Human;Mouse;Rat;Canine;Primate;Bovine

Background :

F-actin-capping-protein subunit beta (CapZ beta) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of an α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. F-actin capping protein subunit beta is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of F-actin capping protein subunit beta’s subunits. While there is almost nothing known regarding the β3 subunit, the β1 and β2 isoforms each have distinct roles. The isoform β2 is predominantly expressed in non-muscle cells and is found in intercalated discs and the cell periphery, but is not observed at Z-discs. Isoform β1 is more greatly expressed in striated muscle and is localized at the Z-discs. It also contains the COOH-terminal extension necessary for capping the actin.

ALT Names :

capping protein (actin filament) muscle Z-line, beta;F-actin capping protein beta subunit

Immunogen :

KLH-conjugated linear peptide corresponding to human F-actin-capping protein subunit beta of the C-terminus of isoform 2.

Specificity :

The antibody recognizes F-actin-capping protein subunit beta at the C-terminus of isoform 2.

Package Size :

50 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt