F-actin-capping protein subunit alpha-1 Antibody | EMD Millipore AB6016 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

F-actin-capping protein subunit alpha-1 Antibody

catalog :

AB6016

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, bovine

application :

western blot, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; loading ...; fig 4f	Malinova D, Fritzsche M, Nowosad C, Armer H, Munro P, Blundell M, et al. WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts. J Leukoc Biol. 2016;99:699-710 pubmed publisher
	Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed

product information

Catalog Number :

AB6016

Subcategory :

Cell Structure

Product Name :

Anti-F-actin-capping protein subunit alpha-1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P52907

Host Name :

Rabbit

Antigen :

F-actin-capping protein subunit alpha-1

Conjugate :

Affinity Purified

Product Description :

Anti-F-actin-capping protein subunit alpha-1 Antibody

Cross Reactivity :

Human;Mouse;Rat;Primate;Rhesus Macaque;Bovine;Pig;Canine

Background :

F-actin capping protein subunit alpha (CapZ alpha) belongs to the F-actin capping protein family, which are characteristic heterodimers, consisting of an α subunit (31-36 kDa) and a β subunit (28-32 kDa), that cap the barbed end of actin filaments within all eukaryotes. Their ability to bind the actin filaments is in a manner independent of Ca2++ and requires the C-terminal end of both subunits for optimal binding. CapZ is contained within the Z-discs of striated muscle, where it functions to inhibit the polymerization and depolymerization of actin. Within vertebrates, there are three isoforms for each of CapZ’s subunits. All three alpha subunit isoforms are components of the WASH complex. Little is known about isoforms 1 and 2; however, isoform 3 is thought to be involved in spermatid morphogenesis and is exclusively observed within sperm and testis, with highest expression within the neck region of sperm.

ALT Names :

capping protein (actin filament) muscle Z-line, alpha 1;CapZ alpha-1;F-actin-capping protein subunit alpha-1

Immunogen :

GST-tagged recombinant protein corres-ponding to human F-actin-capping protein subunit alpha-1.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt