MT1-MMP Antibody, hinge region | EMD Millipore AB6004 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MT1-MMP Antibody, hinge region

catalog :

AB6004

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dogs, bovine

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4a	Bordeleau F, Mason B, Lollis E, Mazzola M, Zanotelli M, Somasegar S, et al. Matrix stiffening promotes a tumor vasculature phenotype. Proc Natl Acad Sci U S A. 2017;114:492-497 pubmed publisher
	Grither W, Divine L, Meller E, Wilke D, Desai R, Loza A, et al. TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis. Oncogene. 2018;37:1714-1729 pubmed publisher
	Donnelly S, Cabrera R, Mao S, Christin J, Wu B, Guo W, et al. Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation. J Cell Biol. 2017;216:4331-4349 pubmed publisher
	Pratt J, Roy R, Annabi B. Concanavalin-A-induced autophagy biomarkers requires membrane type-1 matrix metalloproteinase intracellular signaling in glioblastoma cells. Glycobiology. 2012;22:1245-55 pubmed publisher

product information

Catalog Number :

AB6004

Subcategory :

Cell Structure

Product Name :

Anti-MT1-MMP Antibody, hinge region

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P50281

Host Name :

Rabbit

Antigen :

MT1-MMP

Conjugate :

Affinity Purified

Product Description :

Anti-MT1-MMP Antibody, hinge region

Cross Reactivity :

Human;Rat

Background :

Matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases. Collectively, these enzymes degrade the components of extracellular matrix, including fibrillar and non-fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. MMPs play an important role in wound healing, apoptosis, bone elongation, embryo development, angiogenesis, cancer metastases, and tissue remodeling within many disease states. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, MT1-MMP (MMP-14) is a member of the membrane-type subfamily. Each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. MT1-MMP is capable of mediating pericellular proteolysis of extracellular matrix components and is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix. This protein also activates MMP2 protein, and this activity may be involved in tumor invasion.

ALT Names :

MT-MMP 1;Membrane-type matrix metalloproteinase 1 ;Membrane-type-1 matrix metalloproteinase ;matrix metallopeptidase 14 (membrane-inserted) ;matrix metalloproteinase 14 ;matrix metalloproteinase 14 (membrane-inserted);membrane type 1 metalloprotease

Immunogen :

KLH conjugated synthetic peptide selected from the hinge region of human MT1-MMP.

Specificity :

The antibody recognizes human and rat MT1-MMP. It does not cross react with MMP-1, MMP-2, MMP-8, MMP-9, and MMP-13.

Package Size :

100 µg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Maintain at 2-8°C for up to 1 year from date of receipt.