BACE Antibody, CT | EMD Millipore AB5940 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BACE Antibody, CT

catalog :

AB5940

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

product information

Catalog Number :

AB5940

Subcategory :

Neuroscience

Product Name :

Anti-BACE Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P56817

Host Name :

Rabbit

Antigen :

BACE

Conjugate :

Affinity Purified

Product Description :

Anti-BACE Antibody, CT

Cross Reactivity :

Human

Background :

Alzheimer's disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid b-peptide (Ab). Ab generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of Ab by b-secretase. The Ab peptide is then released by proteolytic cleavage at its C-terminus by g-secretase. Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes.A human transmembrane aspartic-protease (Asp2), referred to as BACE, has been characterized and shown to have all the properties of b-secretase. Four groups in all have now confirmed that BACE (or Asp2) is a convincing candidate for b-secretase. BACE is an N-glycosylated integral membrane aspartyl protease with Mr=70 kDa. Mature BACE is produced from the immature form through a series of post-translational proteolytic cleavages and glycosylation. Sequence analysis has revealed that the immature form of BACE contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form by a signal peptidase located in the endoplasmic reticulum (ER), yielding the proBACE protein (Mr=75 kDa) which starts at residue 22. The proBACE protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE protein.

ALT Names :

ASP2; BACE1; Beta Secretase; beta-Site APP Cleaving Enzyme

Immunogen :

Synthetic peptide corresponding to the C-terminus of human BACE.

Specificity :

BACE (beta-site APP Cleaving Enzyme).

Package Size :

100 µg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.