Tyrosine Hydroxylase Antibody, phosphoSer 40 | EMD Millipore AB5935 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tyrosine Hydroxylase Antibody, phosphoSer 40

catalog :

AB5935

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 5b	Ho T, Lee C, Lu Z, Lane H, Tsai M, Ho I, et al. Effects of Electroacupuncture on Methamphetamine-Induced Behavioral Changes in Mice. Evid Based Complement Alternat Med. 2017;2017:5642708 pubmed publisher
western blot; mouse; 1:1000; fig 7b	Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
	Pristerá A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, et al. Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration. Proc Natl Acad Sci U S A. 2019;116:3817-3826 pubmed publisher
	Colon Perez L, Pino J, Saha K, Pompilus M, Kaplitz S, Choudhury N, et al. Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Neuropharmacology. 2018;137:178-193 pubmed publisher
	Pahng A, Paulsen R, McGinn M, Edwards K, Edwards S. Neurobiological Correlates of Pain Avoidance-Like Behavior in Morphine-Dependent and Non-Dependent Rats. Neuroscience. 2017;366:1-14 pubmed publisher

product information

Catalog Number :

AB5935

Subcategory :

Neuroscience

Product Name :

Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P07101

Host Name :

Rabbit

Antigen :

Tyrosine Hydroxylase

Conjugate :

Affinity Purified

Product Description :

Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

Cross Reactivity :

Rat;Mouse;Human;Avian

Background :

Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.

ALT Names :

Tyrosine Monooxygenase

Immunogen :

Synthetic peptide from the phosphoSer40 of rat Tyrosine Hydroxylase.

Specificity :

Tyrosine Hydroxylase, phosphoSer40. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser40. Depending on brain region being studied, protein loads and detection methods used some higher molecular weight bands may be detected.

Package Size :

100 µL

Uses :

Immunocytochemistry;Immunohistochemistry;Western Blotting

Storage :

Stable for 6 months at -20°C in undiluted from date of receipt.