This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
VGLUT1 AB5905
catalog :
AB5905
quantity :
50 µL
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 96
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 4c
Granger A, Wang W, Robertson K, El Rifai M, Zanello A, Bistrong K, et al. Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region-specific manner. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig 1a
Alles S, Nascimento F, Lujan R, Luiz A, Millet Q, Bangash M, et al. Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability. Sci Adv. 2020;6:eaax4568 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 4a
Barros Viegas A, Carmona V, Ferreiro E, Guedes J, Cardoso A, Cunha P, et al. miRNA-31 Improves Cognition and Abolishes Amyloid-β Pathology by Targeting APP and BACE1 in an Animal Model of Alzheimer's Disease. Mol Ther Nucleic Acids. 2020;19:1219-1236 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 2a
Sclip A, Sudhof T. LAR receptor phospho-tyrosine phosphatases regulate NMDA-receptor responses. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; human; 1:5000; loading ...; fig s1a
Trevino A, Sinnott Armstrong N, Andersen J, Yoon S, Huber N, Pritchard J, et al. Chromatin accessibility dynamics in a model of human forebrain development. Science. 2020;367: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig 2a
Rice H, Marcassa G, Chrysidou I, Horré K, Young Pearse T, Müller U, et al. Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model. Mol Neurodegener. 2020;15:3 pubmed publisher
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 1c
Carceller H, Guirado R, Nacher J. Dark exposure affects plasticity-related molecules and interneurons throughout the visual system during adulthood. J Comp Neurol. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig s1a
Otsu Y, Darcq E, Pietrajtis K, Matyas F, Schwartz E, Bessaih T, et al. Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula. Science. 2019;366:250-254 pubmed publisher
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 3d
Guo H, Li Y, Shen L, Wang T, Jia X, Liu L, et al. Disruptive variants of CSDE1 associate with autism and interfere with neuronal development and synaptic transmission. Sci Adv. 2019;5:eaax2166 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; loading ...; fig 2a
Venkataramani V, Tanev D, Strahle C, Studier Fischer A, Fankhauser L, Kessler T, et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019;573:532-538 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s1a
Orefice L, Mosko J, Morency D, Wells M, Tasnim A, Mozeika S, et al. Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models. Cell. 2019;178:867-886.e24 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig 1b
Wagner W, Lippmann K, Heisler F, Gromova K, Lombino F, Roesler M, et al. Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term Depression. Cell Rep. 2019;28:11-20.e9 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:2000; loading ...; fig 3c
Velasco S, Kedaigle A, Simmons S, Nash A, Rocha M, Quadrato G, et al. Individual brain organoids reproducibly form cell diversity of the human cerebral cortex. Nature. 2019;: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 5a
Kameda H, Murabe N, Odagaki K, Mizukami H, Ozawa K, Sakurai M. Differential innervation within a transverse plane of spinal gray matter by sensorimotor cortices, with special reference to the somatosensory cortices. J Comp Neurol. 2019;527:1401-1415 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 3c
Soiza Reilly M, Meye F, Olusakin J, Telley L, Petit E, Chen X, et al. SSRIs target prefrontal to raphe circuits during development modulating synaptic connectivity and emotional behavior. Mol Psychiatry. 2019;24:726-745 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig s10a
Real R, Peter M, Trabalza A, Khan S, Smith M, Dopp J, et al. In vivo modeling of human neuron dynamics and Down syndrome. Science. 2018;362: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:5000; fig 3s
Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlen M, et al. Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell. 2018;173:153-165.e22 pubmed publisher
  • immunohistochemistry; rat; 1:750; loading ...; fig 8x
Pocratsky A, Burke D, Morehouse J, Beare J, Riegler A, Tsoulfas P, et al. Reversible silencing of lumbar spinal interneurons unmasks a task-specific network for securing hindlimb alternation. Nat Commun. 2017;8:1963 pubmed publisher
  • immunohistochemistry; mouse; 1:5000; fig 4a
Murao N, Yokoi N, Honda K, Han G, Hayami T, Gheni G, et al. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE. 2017;12:e0187213 pubmed publisher
  • immunocytochemistry; human; 1:1000; loading ...; fig 1d
Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed publisher
  • immunocytochemistry; human; 1:500; tbl s1
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 6f
Kim S, Im S, Oh S, Jeong S, Yoon E, Lee C, et al. Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network. Nat Commun. 2017;8:14346 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:1000; fig 1d
Lee I, Koo K, Jung K, Kim M, Kim I, Hwang K, et al. Neurogenin-2-transduced human neural progenitor cells attenuate neonatal hypoxic-ischemic brain injury. Transl Res. 2017;183:121-136.e9 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; tbl 2
Chaney S, Mukherjee S, Giddabasappa A, Rueda E, Hamilton W, Johnson J, et al. Increased proliferation of late-born retinal progenitor cells by gestational lead exposure delays rod and bipolar cell differentiation. Mol Vis. 2016;22:1468-1489 pubmed
  • immunohistochemistry; mouse; 1:4000; loading ...; fig s1a
  • western blot; mouse; 1:5000; loading ...; fig s2a
  • immunocytochemistry; rat; 1:4000; loading ...; fig 1a
Cai Y, Yang L, Hu G, Chen X, Niu F, Yuan L, et al. Regulation of morphine-induced synaptic alterations: Role of oxidative stress, ER stress, and autophagy. J Cell Biol. 2016;215:245-258 pubmed
  • immunohistochemistry - frozen section; mouse; 1:5000; loading ...; fig 6g
  • western blot; mouse; 1:50,000; loading ...; fig 3a
Chen Y, Kuo H, Bornschein U, Takahashi H, Chen S, Lu K, et al. Foxp2 controls synaptic wiring of corticostriatal circuits and vocal communication by opposing Mef2c. Nat Neurosci. 2016;19:1513-1522 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 6a
Bramini M, Sacchetti S, Armirotti A, Rocchi A, Vazquez E, León Castellanos V, et al. Graphene Oxide Nanosheets Disrupt Lipid Composition, Ca(2+) Homeostasis, and Synaptic Transmission in Primary Cortical Neurons. ACS Nano. 2016;10:7154-71 pubmed publisher
  • immunocytochemistry; rat; fig 8
Yokoi N, Fukata Y, Sekiya A, Murakami T, Kobayashi K, Fukata M. Identification of PSD-95 Depalmitoylating Enzymes. J Neurosci. 2016;36:6431-44 pubmed publisher
  • immunocytochemistry; mouse; 1:3000; fig 2
Xia M, Zhu S, Shevelkin A, Ross C, Pletnikov M. DISC1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders. J Neurochem. 2016;138:518-24 pubmed publisher
  • immunocytochemistry; mouse; 1:4000; fig 3
Buren C, Tu G, Parsons M, Sepers M, Raymond L. Influence of cortical synaptic input on striatal neuronal dendritic arborization and sensitivity to excitotoxicity in corticostriatal coculture. J Neurophysiol. 2016;116:380-90 pubmed publisher
  • immunocytochemistry; human; fig s2
Kim E, Jeon C, Lee S, Hwang I, Chung T. Robust Type-specific Hemisynapses Induced by Artificial Dendrites. Sci Rep. 2016;6:24210 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; fig 4
Miyata S, Kitagawa H. Chondroitin 6-Sulfation Regulates Perineuronal Net Formation by Controlling the Stability of Aggrecan. Neural Plast. 2016;2016:1305801 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 6
Li W, Xu X, Pozzo Miller L. Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors. Proc Natl Acad Sci U S A. 2016;113:E1575-84 pubmed publisher
  • immunohistochemistry; rat; loading ...; fig 3d
Wagner F, Bernard R, Derst C, French L, Veh R. Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance. Brain Struct Funct. 2016;221:4663-4689 pubmed
  • immunohistochemistry - frozen section; human; 1:1000; fig 6
Sekar A, Bialas A, de Rivera H, Davis A, Hammond T, Kamitaki N, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177-83 pubmed publisher
  • immunohistochemistry; mouse; 1:10,000; fig 6
Grant E, Hoerder Suabedissen A, Molnár Z. The Regulation of Corticofugal Fiber Targeting by Retinal Inputs. Cereb Cortex. 2016;26:1336-1348 pubmed publisher
  • immunocytochemistry; mouse; 1:2000; tbl 1
Hirata H, Umemori J, Yoshioka H, Koide T, Watanabe K, Shimoda Y. Cell adhesion molecule contactin-associated protein 3 is expressed in the mouse basal ganglia during early postnatal stages. J Neurosci Res. 2016;94:74-89 pubmed publisher
Zhang R, Liakath Ali K, Sudhof T. Latrophilin-2 and latrophilin-3 are redundantly essential for parallel-fiber synapse function in cerebellum. elife. 2020;9: pubmed publisher
Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019;104:749-764.e6 pubmed publisher
Holt L, Hernandez R, Pacheco N, Torres Ceja B, Hossain M, Olsen M. Astrocyte morphogenesis is dependent on BDNF signaling via astrocytic TrkB.T1. elife. 2019;8: pubmed publisher
Heusinger J, Hildebrandt H, Illing R. Sensory deafferentation modulates and redistributes neurocan in the rat auditory brainstem. Brain Behav. 2019;9:e01353 pubmed publisher
Tong D, Chen R, Lu Y, Li W, Zhang Y, Lin J, et al. The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice. Neurobiol Dis. 2019;130:104486 pubmed publisher
Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, et al. GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice. Sci Rep. 2019;9:7132 pubmed publisher
Takeoka A, Arber S. Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury. Cell Rep. 2019;27:71-85.e3 pubmed publisher
Edfawy M, Guedes J, Pereira M, Laranjo M, Carvalho M, Gao X, et al. Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice. Nat Commun. 2019;10:1431 pubmed publisher
Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Matsumoto Y, et al. Layer-specific expression of extracellular matrix molecules in the mouse somatosensory and piriform cortices. IBRO Rep. 2019;6:1-17 pubmed publisher
Reynolds J, Zheng K, Rusakov D. Multiplexed calcium imaging of single-synapse activity and astroglial responses in the intact brain. Neurosci Lett. 2019;689:26-32 pubmed publisher
Kobayakawa Y, Masaki K, Yamasaki R, Shiraishi W, Hayashida S, Hayashi S, et al. Downregulation of Neuronal and Dendritic Connexin36-Made Electrical Synapses Without Glutamatergic Axon Terminals in Spinal Anterior Horn Cells From the Early Stage of Amyotrophic Lateral Sclerosis. Front Neurosci. 2018;12:894 pubmed publisher
Comhair J, Devoght J, Morelli G, Harvey R, Briz V, Borrie S, et al. Alpha2-Containing Glycine Receptors Promote Neonatal Spontaneous Activity of Striatal Medium Spiny Neurons and Support Maturation of Glutamatergic Inputs. Front Mol Neurosci. 2018;11:380 pubmed publisher
Blanco Suarez E, Liu T, Kopelevich A, Allen N. Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors. Neuron. 2018;100:1116-1132.e13 pubmed publisher
Letellier M, Szíber Z, Chamma I, Saphy C, Papasideri I, Tessier B, et al. A unique intracellular tyrosine in neuroligin-1 regulates AMPA receptor recruitment during synapse differentiation and potentiation. Nat Commun. 2018;9:3979 pubmed publisher
Morello N, Schina R, Pilotto F, Phillips M, Melani R, Plicato O, et al. Loss of Mecp2 Causes Atypical Synaptic and Molecular Plasticity of Parvalbumin-Expressing Interneurons Reflecting Rett Syndrome-Like Sensorimotor Defects. Eneuro. 2018;5: pubmed publisher
Nestor J, Arinuma Y, Huerta T, Kowal C, Nasiri E, Kello N, et al. Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors. J Exp Med. 2018;215:2554-2566 pubmed publisher
Persoon C, Moro A, Nassal J, Farina M, Broeke J, Arora S, et al. Pool size estimations for dense-core vesicles in mammalian CNS neurons. EMBO J. 2018;37: pubmed publisher
Emperador Melero J, Huson V, Van Weering J, Bollmann C, Fischer von Mollard G, Toonen R, et al. Vti1a/b regulate synaptic vesicle and dense core vesicle secretion via protein sorting at the Golgi. Nat Commun. 2018;9:3421 pubmed publisher
Krasovska V, Doering L. Regulation of IL-6 Secretion by Astrocytes via TLR4 in the Fragile X Mouse Model. Front Mol Neurosci. 2018;11:272 pubmed publisher
Zhang P, Lu H, Peixoto R, Pines M, Ge Y, Oku S, et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018;174:1450-1464.e23 pubmed publisher
Simhal A, Gong B, Trimmer J, Weinberg R, Smith S, Sapiro G, et al. A Computational Synaptic Antibody Characterization Tool for Array Tomography. Front Neuroanat. 2018;12:51 pubmed publisher
Risher W, Kim N, Koh S, Choi J, Mitev P, Spence E, et al. Thrombospondin receptor α2δ-1 promotes synaptogenesis and spinogenesis via postsynaptic Rac1. J Cell Biol. 2018;217:3747-3765 pubmed publisher
Chang R, Eriksen J, Edwards R. The dual role of chloride in synaptic vesicle glutamate transport. elife. 2018;7: pubmed publisher
Rhomberg T, Rovira Esteban L, Vikór A, Paradiso E, Kremser C, Nagy Pál P, et al. Vasoactive Intestinal Polypeptide-Immunoreactive Interneurons within Circuits of the Mouse Basolateral Amygdala. J Neurosci. 2018;38:6983-7003 pubmed publisher
Nagappan Chettiar S, Johnson Venkatesh E, Umemori H. Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation. J Biol Chem. 2018;293:12026-12042 pubmed publisher
Takeuchi H, Horie S, Moritoh S, Matsushima H, Hori T, Kimori Y, et al. Different Activity Patterns in Retinal Ganglion Cells of TRPM1 and mGluR6 Knockout Mice. Biomed Res Int. 2018;2018:2963232 pubmed publisher
Ueno M, Nakamura Y, Li J, Gu Z, Niehaus J, Maezawa M, et al. Corticospinal Circuits from the Sensory and Motor Cortices Differentially Regulate Skilled Movements through Distinct Spinal Interneurons. Cell Rep. 2018;23:1286-1300.e7 pubmed publisher
Hruska M, Henderson N, Le Marchand S, Jafri H, Dalva M. Synaptic nanomodules underlie the organization and plasticity of spine synapses. Nat Neurosci. 2018;21:671-682 pubmed publisher
Kelley K, Ben Haim L, Schirmer L, Tyzack G, Tolman M, Miller J, et al. Kir4.1-Dependent Astrocyte-Fast Motor Neuron Interactions Are Required for Peak Strength. Neuron. 2018;98:306-319.e7 pubmed publisher
Bird E, Iannitti T, Christmas C, Obara I, Andreev V, King A, et al. A Novel Role for Lymphotactin (XCL1) Signaling in the Nervous System: XCL1 Acts via its Receptor XCR1 to Increase Trigeminal Neuronal Excitability. Neuroscience. 2018;379:334-349 pubmed publisher
Jung H, Yoo D, Park J, Kim J, Chung J, Kim D, et al. Age-dependent changes in vesicular glutamate transporter 1 and 2 expression in the gerbil hippocampus. Mol Med Rep. 2018;17:6465-6471 pubmed publisher
Lin T, Tan Z, Barik A, Yin D, Brudvik E, Wang H, et al. Regulation of Synapse Development by Vgat Deletion from ErbB4-Positive Interneurons. J Neurosci. 2018;38:2533-2550 pubmed publisher
Oda S, Tsuneoka Y, Yoshida S, Adachi Akahane S, Ito M, Kuroda M, et al. Immunolocalization of muscarinic M1 receptor in the rat medial prefrontal cortex. J Comp Neurol. 2018;526:1329-1350 pubmed publisher
Cserép C, Pósfai B, Schwarcz A, Denes A. Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites. Eneuro. 2018;5: pubmed publisher
Farhy Tselnicker I, van Casteren A, Lee A, Chang V, Aricescu A, Allen N. Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation. Neuron. 2017;96:428-445.e13 pubmed publisher
Litvina E, Chen C. Functional Convergence at the Retinogeniculate Synapse. Neuron. 2017;96:330-338.e5 pubmed publisher
Anderson G, Maxeiner S, Sando R, Tsetsenis T, Malenka R, Südhof T. Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly. J Cell Biol. 2017;216:3831-3846 pubmed publisher
Basu R, Duan X, Taylor M, Martin E, Muralidhar S, Wang Y, et al. Heterophilic Type II Cadherins Are Required for High-Magnitude Synaptic Potentiation in the Hippocampus. Neuron. 2017;96:160-176.e8 pubmed publisher
Luo F, Liu X, Sudhof T, Acuna C. Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca2+ channels. Proc Natl Acad Sci U S A. 2017;114:E8081-E8090 pubmed publisher
Labonte B, Engmann O, Purushothaman I, Menard C, Wang J, Tan C, et al. Sex-specific transcriptional signatures in human depression. Nat Med. 2017;23:1102-1111 pubmed publisher
Favuzzi E, Marques Smith A, Deogracias R, Winterflood C, Sánchez Aguilera A, Mantoan L, et al. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron. 2017;95:639-655.e10 pubmed publisher
Liu Z, Chen Z, Shang C, Yan F, Shi Y, Zhang J, et al. IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning. Neuron. 2017;95:106-122.e5 pubmed publisher
Bellesi M, de Vivo L, Chini M, Gilli F, Tononi G, Cirelli C. Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex. J Neurosci. 2017;37:5263-5273 pubmed publisher
Birey F, Andersen J, Makinson C, Islam S, Wei W, Huber N, et al. Assembly of functionally integrated human forebrain spheroids. Nature. 2017;545:54-59 pubmed publisher
Sierksma M, Borst J. Resistance to action potential depression of a rat axon terminal in vivo. Proc Natl Acad Sci U S A. 2017;114:4249-4254 pubmed publisher
Wu D, Bacaj T, Morishita W, Goswami D, Arendt K, Xu W, et al. Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Nature. 2017;544:316-321 pubmed publisher
Divakaruni A, Wallace M, Buren C, Martyniuk K, Andreyev A, Li E, et al. Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death. J Cell Biol. 2017;216:1091-1105 pubmed publisher
Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
Lagerlöf O, Hart G, Huganir R. O-GlcNAc transferase regulates excitatory synapse maturity. Proc Natl Acad Sci U S A. 2017;114:1684-1689 pubmed publisher
Sonner M, Walters M, Ladle D. Analysis of Proprioceptive Sensory Innervation of the Mouse Soleus: A Whole-Mount Muscle Approach. PLoS ONE. 2017;12:e0170751 pubmed publisher
Ashrafi G, Wu Z, Farrell R, Ryan T. GLUT4 Mobilization Supports Energetic Demands of Active Synapses. Neuron. 2017;93:606-615.e3 pubmed publisher
Abraira V, Kuehn E, Chirila A, Springel M, Toliver A, Zimmerman A, et al. The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn. Cell. 2017;168:295-310.e19 pubmed publisher
Wang G, Smith S, Mourrain P. Sub-synaptic, multiplexed analysis of proteins reveals Fragile X related protein 2 is mislocalized in Fmr1 KO synapses. elife. 2016;5: pubmed publisher
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Terauchi A, Johnson Venkatesh E, Bullock B, Lehtinen M, Umemori H. Retrograde fibroblast growth factor 22 (FGF22) signaling regulates insulin-like growth factor 2 (IGF2) expression for activity-dependent synapse stabilization in the mammalian brain. elife. 2016;5: pubmed publisher
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Hu H, Ho W, Mackie K, Pittman Q, Sharkey K. Brain CB? receptor expression following lipopolysaccharide-induced inflammation. Neuroscience. 2012;227:211-22 pubmed publisher
Dobi A, Margolis E, Wang H, Harvey B, Morales M. Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons. J Neurosci. 2010;30:218-29 pubmed publisher
product information
Catalog Number :
AB5905
Subcategory :
Neuroscience
Product Name :
Anti-VGLUT1 AB5905
Product Type :
Antibodies
Clonality :
Polyclonal Antibody
Gene ID :
Q62634
Host Name :
Guinea Pig
Antigen :
VGLUT1 AB5905
Conjugate :
Serum
Product Description :
Anti-VGLUT1 AB5905
Cross Reactivity :
Rat;Human
Background :
VGLUT1 is expressed in a subset of glutamate neurons and transports glutamate into native synaptic vesicles from the brain, exhibiting a conductance for chloride that is blocked by glutamate. Vesicular glutamate transport has a substantially lower apparent affinity than the plasma membrane excitatory amino acid transporters. Glutamate transport by VGLUT1 is saturated with a K(m) of approximately 2 mM, in the same range as transport by synaptic vesicles. Finally, plasma membrane glutamate transporters recognize both aspartate and glutamate as substrates, whereas VGLUT1 does not recognize aspartate. Vesicular glutamate transporters pack the neurotransmitter into synaptic vesicles so that they can be released into the synapse. VGLUTs are dependent on a proton gradient that they create by hydrolysing adenosine triphosphate (ATP). VGLUTs have only between one hundredth and one thousandth the affinity for glutamate that EAATs have.
ALT Names :
Vesicular glutamate transporter 1;VGluT1;Brain-specific Na(+)-dependent inorganic phosphate cotransporter;Solute carrier family 17 member 7
Immunogen :
Bovine Thyroid Globulin-conjugated linear peptide corresponding to the C-terminus of rat VGLUT1.
Specificity :
Cat. No. AB5905 is specific to Vesicular Glutamate Transporter 1 (VGLUT1). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence and histochemistry. The antiserum mainly labels nerve fibers and terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide Preabsorption of the VGLUT1 antiserum with immunogen peptide (Cat. No. AG208) eliminates all immunostaining.
Package Size :
50 µL
Uses :
Immunohistochemistry
Storage :
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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