Dab1 Antibody | EMD Millipore AB5840 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dab1 Antibody

catalog :

AB5840

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 1e western blot; mouse; 1:1000; loading ...; fig 3a	Fairchild C, Hino K, Han J, Miltner A, Peinado Allina G, Brown C, et al. RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018;145: pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 2f	Ha S, Tripathi P, Mihalas A, Hevner R, Beier D. C-Terminal Region Truncation of RELN Disrupts an Interaction with VLDLR, Causing Abnormal Development of the Cerebral Cortex and Hippocampus. J Neurosci. 2017;37:960-971 pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig 6c	Broix L, Jagline H, Ivanova E, Schmucker S, Drouot N, Clayton Smith J, et al. Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia. Nat Genet. 2016;48:1349-1358 pubmed publisher
	Wang S, Brunne B, Zhao S, Chai X, Li J, Lau J, et al. Trajectory Analysis Unveils Reelin's Role in the Directed Migration of Granule Cells in the Dentate Gyrus. J Neurosci. 2018;38:137-148 pubmed publisher
	Kozuka T, Chaya T, Tamalu F, Shimada M, Fujimaki Aoba K, Kuwahara R, et al. The TRPM1 Channel Is Required for Development of the Rod ON Bipolar Cell-AII Amacrine Cell Pathway in the Retinal Circuit. J Neurosci. 2017;37:9889-9900 pubmed publisher
	Jakob B, Kochlamazashvili G, Jäpel M, Gauhar A, Bock H, Maritzen T, et al. Intersectin 1 is a component of the Reelin pathway to regulate neuronal migration and synaptic plasticity in the hippocampus. Proc Natl Acad Sci U S A. 2017;114:5533-5538 pubmed publisher

product information

Catalog Number :

AB5840

Subcategory :

Neuroscience

Product Name :

Anti-Dab1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O75553

Host Name :

Rabbit

Antigen :

Dab1

Conjugate :

Serum

Product Description :

Anti-Dab1 Antibody

Cross Reactivity :

Mouse

Background :

Dab1 is a protein arising from the mouse gene dab, that is related to the Drosophila gene 'disabled'. Mutations in the mouse dab gene may result in the 'scrambler' and 'yotari' phenotypes. Dab encodes a phosphoprotein that binds non-receptor tyrosine kinases and has been implicated in neuron development. Dab1 is expressed in neuronal populations exposed to reelin, as determined by in situ hybridization to embryonic mouse brain tissue. Dab1 may function as a signaling molecule that regulates positioning in the developing brain. Cloning of human DAB1 and sequence determinations suggests a 96% homology to the mouse sequence. Very low density lipoprotein receptors (VLDLR) and apolipoprotein E receptor-2 (APOER2) both bind Dab1 on their cytoplasmic tails. Dab1 expression is upregulated in knockout mice lacking both Vldlr and Apoer2 genes.

ALT Names :

Disabled homolog 1

Immunogen :

Highly purified GST-fusion protein corresponding to residues 400-555 of mouse Dab1.

Specificity :

On western blots of mouse brain extracts, the antibody recognizes a band migrating at approximately 80 kDa corresponding to Dab1. No cross reactivity to human or mouse Dab2.

Package Size :

100 μL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.