This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
map 2,map2
catalog :
AB5622
clonality :
polyclonal
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 67
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 1b
Bruyère J, Abada Y, Vitet H, Fontaine G, Deloulme J, Ces A, et al. Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin. elife. 2020;9: pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 4e
Matsumura K, Seiriki K, Okada S, Nagase M, Ayabe S, Yamada I, et al. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes. Nat Commun. 2020;11:859 pubmed publisher
  • immunocytochemistry; rat; loading ...; fig s1b
Lee M, Liu Y, Chen C, Lu C, Lu S, Huang T, et al. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. J Cell Biol. 2020;219: pubmed publisher
  • immunocytochemistry; mouse; 1:500; loading ...; fig 2a, 2s1b
  • immunocytochemistry; human; 1:500; loading ...; fig 2s1c
Yang D, Qu F, Cai H, Chuang C, Lim J, Jahchan N, et al. Axon-like protrusions promote small cell lung cancer migration and metastasis. elife. 2019;8: pubmed publisher
  • immunocytochemistry; rat; loading ...; fig 4d
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson E, et al. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Nat Commun. 2019;10:5583 pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 1a
Vierra N, Kirmiz M, van der List D, Santana L, Trimmer J. Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons. elife. 2019;8: pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 3a
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, et al. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. EMBO Mol Med. 2019;11: pubmed publisher
  • immunocytochemistry; rat; 1:1000; loading ...; fig 3c
Van Laar V, Arnold B, Howlett E, Calderon M, St Croix C, Greenamyre J, et al. Evidence for Compartmentalized Axonal Mitochondrial Biogenesis: Mitochondrial DNA Replication Increases in Distal Axons As an Early Response to Parkinson's Disease-Relevant Stress. J Neurosci. 2018;38:7505-7515 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig s1e
Freixo F, Martínez Delgado P, Manso Y, Sánchez Huertas C, Lacasa C, Soriano E, et al. NEK7 regulates dendrite morphogenesis in neurons via Eg5-dependent microtubule stabilization. Nat Commun. 2018;9:2330 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig s23
Sousa A, Zhu Y, Raghanti M, Kitchen R, Onorati M, Tebbenkamp A, et al. Molecular and cellular reorganization of neural circuits in the human lineage. Science. 2017;358:1027-1032 pubmed publisher
  • immunohistochemistry; mouse; 1:400; fig 8b
  • western blot; mouse; 1:500; loading ...; fig 3i
Tseng K, Danilova T, Domanskyi A, Saarma M, Lindahl M, Airavaara M. MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex. Eneuro. 2017;4: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 5c
Kannan M, Bayam E, Wagner C, Rinaldi B, Kretz P, Tilly P, et al. WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy. Proc Natl Acad Sci U S A. 2017;114:E9308-E9317 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 5a, 5b
Tseng J, Xie L, Song S, Xie Y, Allen L, Ajit D, et al. The Deacetylase HDAC6 Mediates Endogenous Neuritic Tau Pathology. Cell Rep. 2017;20:2169-2183 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig 6b
Skariah G, Seimetz J, Norsworthy M, Lannom M, Kenny P, Elrakhawy M, et al. Mov10 suppresses retroelements and regulates neuronal development and function in the developing brain. BMC Biol. 2017;15:54 pubmed publisher
  • immunocytochemistry; mouse; 1:1000; loading ...; fig s8
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 5c
Takano T, Wu M, Nakamuta S, Naoki H, Ishizawa N, Namba T, et al. Discovery of long-range inhibitory signaling to ensure single axon formation. Nat Commun. 2017;8:33 pubmed publisher
  • immunocytochemistry; human; 1:500; tbl s1
Yasui T, Uezono N, Nakashima H, Noguchi H, Matsuda T, Noda Andoh T, et al. Hypoxia Epigenetically Confers Astrocytic Differentiation Potential on Human Pluripotent Cell-Derived Neural Precursor Cells. Stem Cell Reports. 2017;8:1743-1756 pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig 4f
Barazzuol L, Ju L, Jeggo P. A coordinated DNA damage response promotes adult quiescent neural stem cell activation. PLoS Biol. 2017;15:e2001264 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5c
  • western blot; mouse; fig 5a
Li J, Barrero C, Merali S, Pratico D. Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype. Sci Rep. 2017;7:46002 pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 7c
Jongbloets B, Lemstra S, Schellino R, Broekhoven M, Parkash J, Hellemons A, et al. Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors. Nat Commun. 2017;8:14666 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 3b
Genç B, Jara J, Lagrimas A, Pytel P, Roos R, Mesulam M, et al. Apical dendrite degeneration, a novel cellular pathology for Betz cells in ALS. Sci Rep. 2017;7:41765 pubmed publisher
  • western blot; rat; 1:2000; fig 6a
McQuail J, Beas B, Kelly K, Simpson K, Frazier C, Setlow B, et al. NR2A-Containing NMDARs in the Prefrontal Cortex Are Required for Working Memory and Associated with Age-Related Cognitive Decline. J Neurosci. 2016;36:12537-12548 pubmed
  • immunocytochemistry; rat; 1:500; fig 1b
Jin L, Lange W, Kempmann A, Maybeck V, Gunther A, Gruteser N, et al. High-efficiency transduction and specific expression of ChR2opt for optogenetic manipulation of primary cortical neurons mediated by recombinant adeno-associated viruses. J Biotechnol. 2016;233:171-80 pubmed publisher
  • immunocytochemistry; rat; 1:500; loading ...; tbl 3
Bartelt Kirbach B, Moron M, Glomb M, Beck C, Weller M, Golenhofen N. HspB5/?B-crystallin increases dendritic complexity and protects the dendritic arbor during heat shock in cultured rat hippocampal neurons. Cell Mol Life Sci. 2016;73:3761-75 pubmed publisher
  • immunocytochemistry; mouse; 1:250; loading ...; fig 4d
Iyer N, Huettner J, Butts J, Brown C, Sakiyama Elbert S. Generation of highly enriched V2a interneurons from mouse embryonic stem cells. Exp Neurol. 2016;277:305-316 pubmed publisher
Prpar Mihevc S, Kokondoska Grgich V, Kopitar A, Mohorič L, Majdic G. Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells. BMC Vet Res. 2020;16:282 pubmed publisher
Kitajima R, Nakai R, Imamura T, Kameda T, Kozuka D, Hirai H, et al. Modeling of early neural development in vitro by direct neurosphere formation culture of chimpanzee induced pluripotent stem cells. Stem Cell Res. 2020;44:101749 pubmed publisher
Hunyadi A, Gaál B, Matesz C, Mészár Z, Morawski M, Reimann K, et al. Distribution and classification of the extracellular matrix in the olfactory bulb. Brain Struct Funct. 2020;225:321-344 pubmed publisher
Tiscione S, Vivas O, Ginsburg K, Bers D, Ory D, Santana L, et al. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity. J Cell Biol. 2019;218:4141-4156 pubmed publisher
Sohn P, Huang C, Yan R, Fan L, Tracy T, Camargo C, et al. Pathogenic Tau Impairs Axon Initial Segment Plasticity and Excitability Homeostasis. Neuron. 2019;104:458-470.e5 pubmed publisher
Gao L, Zhang Z, Lu J, Pei G. Mitochondria Are Dynamically Transferring Between Human Neural Cells and Alexander Disease-Associated GFAP Mutations Impair the Astrocytic Transfer. Front Cell Neurosci. 2019;13:316 pubmed publisher
Farfel Becker T, Roney J, Cheng X, Li S, Cuddy S, Sheng Z. Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Cell Rep. 2019;28:51-64.e4 pubmed publisher
Koster K, Francesconi W, Berton F, Alahmadi S, Srinivas R, Yoshii A. Developmental NMDA receptor dysregulation in the infantile neuronal ceroid lipofuscinosis mouse model. elife. 2019;8: pubmed publisher
Zhang J, He L, Yang Z, Li L, Cai W. Lithium chloride promotes proliferation of neural stem cells in vitro, possibly by triggering the Wnt signaling pathway. Anim Cells Syst (Seoul). 2019;23:32-41 pubmed publisher
D Aiuto L, Bloom D, Naciri J, Smith A, Edwards T, McClain L, et al. Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells. J Virol. 2019;93: pubmed publisher
Li J, Chiu J, Pratico D. Full recovery of the Alzheimer's disease phenotype by gain of function of vacuolar protein sorting 35. Mol Psychiatry. 2019;: pubmed publisher
Jiang L, Ash P, Maziuk B, Ballance H, Boudeau S, Abdullatif A, et al. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathol. 2019;137:259-277 pubmed publisher
Finelli M, Aprile D, Castroflorio E, Jeans A, Moschetta M, Chessum L, et al. The epilepsy-associated protein TBC1D24 is required for normal development, survival and vesicle trafficking in mammalian neurons. Hum Mol Genet. 2019;28:584-597 pubmed publisher
Pradier L, Blanchard Bregeon V, Bohme A, Debeir T, Menager J, Benoit P, et al. SAR228810: an antibody for protofibrillar amyloid β peptide designed to reduce the risk of amyloid-related imaging abnormalities (ARIA). Alzheimers Res Ther. 2018;10:117 pubmed publisher
Choi S, Kim Y, Park Y, Yang H, Jeong P, Cha J, et al. Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis. Cell Death Differ. 2018;: pubmed publisher
Mitchell S, Iwabuchi S, Kawano H, Yuen T, Koh J, Ho K, et al. Structure of the Golgi apparatus is not influenced by a GAG deletion mutation in the dystonia-associated gene Tor1a. PLoS ONE. 2018;13:e0206123 pubmed publisher
Gonzalez C, Armijo E, Bravo Alegria J, Becerra Calixto A, Mays C, Soto C. Modeling amyloid beta and tau pathology in human cerebral organoids. Mol Psychiatry. 2018;23:2363-2374 pubmed publisher
Haenfler J, Skariah G, Rodriguez C, Monteiro da Rocha A, Parent J, Smith G, et al. Targeted Reactivation of FMR1 Transcription in Fragile X Syndrome Embryonic Stem Cells. Front Mol Neurosci. 2018;11:282 pubmed publisher
Ma W, Jin G, Gehret P, Chada N, Suh W. A Novel Cell Penetrating Peptide for the Differentiation of Human Neural Stem Cells. Biomolecules. 2018;8: pubmed publisher
Ran Y, Liu Z, Huang S, Shen J, Li F, Zhang W, et al. Splenectomy Fails to Provide Long-Term Protection Against Ischemic Stroke. Aging Dis. 2018;9:467-479 pubmed publisher
López Tobón A, Suresh M, Jin J, Vitriolo A, Pietralla T, Tedford K, et al. The guanine nucleotide exchange factor Arhgef7/?Pix promotes axon formation upstream of TC10. Sci Rep. 2018;8:8811 pubmed publisher
Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald Altman S, Inbar S, et al. miR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption via a Non-Cell-Autonomous Mechanism in ALS. J Neurosci. 2018;38:5478-5494 pubmed publisher
Yakoub A, Sadek M. Development and Characterization of Human Cerebral Organoids: An Optimized Protocol. Cell Transplant. 2018;27:393-406 pubmed publisher
Cheng X, Xie Y, Zhou B, Huang N, Farfel Becker T, Sheng Z. Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. J Cell Biol. 2018;217:3127-3139 pubmed publisher
Nakashima H, Tsujimura K, Irie K, Ishizu M, Pan M, Kameda T, et al. Canonical TGF-? Signaling Negatively Regulates Neuronal Morphogenesis through TGIF/Smad Complex-Mediated CRMP2 Suppression. J Neurosci. 2018;38:4791-4810 pubmed publisher
Rauch J, Chen J, Sorum A, Miller G, Sharf T, See S, et al. Tau Internalization is Regulated by 6-O Sulfation on Heparan Sulfate Proteoglycans (HSPGs). Sci Rep. 2018;8:6382 pubmed publisher
Casarotto P, Biojone C, Montezuma K, Cunha F, Joca S, Castren E, et al. Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania. Peerj. 2018;6:e4635 pubmed publisher
Wang C, Najm R, Xu Q, Jeong D, Walker D, Balestra M, et al. Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med. 2018;24:647-657 pubmed publisher
Morel C, Sherrin T, Kennedy N, Forest K, Avcioglu Barutcu S, Robles M, et al. JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial Memory. J Neurosci. 2018;38:3708-3728 pubmed publisher
Yang C, Li X, Wu Y, Shen Q, Zeng Y, Xiong Q, et al. Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes. Nat Commun. 2018;9:838 pubmed publisher
Ding B, Dobner P, Mullikin Kilpatrick D, Wang W, Zhu H, Chow C, et al. BDNF Activates an NFI-Dependent Neurodevelopmental Timing Program By Sequestering NFATc4. Mol Biol Cell. 2018;: pubmed publisher
Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha. Glia. 2018;66:1016-1033 pubmed publisher
Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, et al. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. PLoS Genet. 2018;14:e1007169 pubmed publisher
Chang T, Chen C, Lee M, Chang Y, Lu C, Lu S, et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. elife. 2017;6: pubmed publisher
Ong D, Hu B, Ho Y, Sauvé C, Bristow C, Wang Q, et al. PAF promotes stemness and radioresistance of glioma stem cells. Proc Natl Acad Sci U S A. 2017;114:E9086-E9095 pubmed publisher
Westerlund I, Shi Y, Toskas K, Fell S, Li S, Surova O, et al. Combined epigenetic and differentiation-based treatment inhibits neuroblastoma tumor growth and links HIF2α to tumor suppression. Proc Natl Acad Sci U S A. 2017;114:E6137-E6146 pubmed publisher
Efimova N, Korobova F, Stankewich M, Moberly A, Stolz D, Wang J, et al. ?III Spectrin Is Necessary for Formation of the Constricted Neck of Dendritic Spines and Regulation of Synaptic Activity in Neurons. J Neurosci. 2017;37:6442-6459 pubmed publisher
Paci P, Gabriele S, Ris L. A new method allowing long-term potentiation recordings in hippocampal organotypic slices. Brain Behav. 2017;7:e00692 pubmed publisher
Olsen R, Otero J, García López J, Wallace K, Finkelstein D, Rehg J, et al. MYCN induces neuroblastoma in primary neural crest cells. Oncogene. 2017;36:5075-5082 pubmed publisher
Tajiri N, Quach D, Kaneko Y, Wu S, Lee D, Lam T, et al. NSI-189, a small molecule with neurogenic properties, exerts behavioral, and neurostructural benefits in stroke rats. J Cell Physiol. 2017;232:2731-2740 pubmed publisher
Vincent K, Cornea V, Jong Y, Laferriere A, Kumar N, Mickeviciute A, et al. Intracellular mGluR5 plays a critical role in neuropathic pain. Nat Commun. 2016;7:10604 pubmed publisher
Cannon J, Geghman K, Tapias V, Sew T, Dail M, Li C, et al. Expression of human E46K-mutated ?-synuclein in BAC-transgenic rats replicates early-stage Parkinson's disease features and enhances vulnerability to mitochondrial impairment. Exp Neurol. 2013;240:44-56 pubmed publisher
Bajsarowicz K, Ahn M, Ackerman L, Dearmond B, Carlson G, Dearmond S. A brain aggregate model gives new insights into the pathobiology and treatment of prion diseases. J Neuropathol Exp Neurol. 2012;71:449-66 pubmed publisher
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
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View all the new antibodies at www.emdmillipore.com.