4-Hydroxynonenal Antibody | EMD Millipore AB5605 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

4-Hydroxynonenal Antibody

catalog :

AB5605

quantity :

200 µL

clonality :

polyclonal

host :

domestic goat

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig s10c	Xue X, Bredell B, Anderson E, Martin A, Mays C, Nagao Kitamoto H, et al. Quantitative proteomics identifies STEAP4 as a critical regulator of mitochondrial dysfunction linking inflammation and colon cancer. Proc Natl Acad Sci U S A. 2017;114:E9608-E9617 pubmed publisher
western blot; mouse; fig 4	Ge W, Yuan M, Ceylan A, Wang X, Ren J. Mitochondrial aldehyde dehydrogenase protects against doxorubicin cardiotoxicity through a transient receptor potential channel vanilloid 1-mediated mechanism. Biochim Biophys Acta. 2016;1862:622-634 pubmed publisher
	Carrageta D, Guerra Carvalho B, Sousa M, Barros A, Oliveira P, Monteiro M, et al. Mitochondrial Activation and Reactive Oxygen-Species Overproduction during Sperm Capacitation are Independent of Glucose Stimuli. Antioxidants (Basel). 2020;9: pubmed publisher
	Sguizzato M, Mariani P, Spinozzi F, Benedusi M, Cervellati F, Cortesi R, et al. Ethosomes for Coenzyme Q10 Cutaneous Administration: From Design to 3D Skin Tissue Evaluation. Antioxidants (Basel). 2020;9: pubmed publisher

product information

Catalog Number :

AB5605

Subcategory :

Neuroscience

Product Name :

Anti-4-Hydroxynonenal Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Host Name :

Goat

Antigen :

4-Hydroxynonenal

Conjugate :

Serum

Product Description :

Anti-4-Hydroxynonenal Antibody

Cross Reactivity :

Human

Background :

The peroxidation of membrane lipids by free radicals is a well-controlled, ongoing process that occurs during normal cell turnover and the normal aging process. There is also the uncontrolled process of free radical production and increased lipid peroxidation that is associated with hepatic injury as a consequence of exposure to halogenated hydrocarbons, excessive alcohol abuse, and acute or chronic iron overload. Excess free radical production and lipid peroxidation is thought to be an etiological factor in such diseases as atherosclerosis, diabetes, genetic hemochromatosis, cancer and neurodegenerative diseases, such as Alzheimer's and Parkinson's disease.4-Hydroxynonenal (HNE) is a highly reactive, cytotoxic aldehyde that is released during the oxidation of w-6-unsaturated fatty acids. HNE can efficiently react with sulfhydryl groups or histidine and lysine groups of proteins to form stable HNE-protein adducts, in addition to phospholipids and nucleic acids. It is through this HNE-modification of biomolecules that HNE is thought to exert its cytotoxic effects. This multifunctional molecule may be considered as a "second toxic messenger," which disseminates and augments initial free radical events. It is believed to be largely responsible for the cytopathological effects observed during oxidative stress. High levels of 4-HNE have been detected in a large number of disease states, indicating some involvement of this aldehyde in their pathogenesis. Some of the prominent pathobiochemical effects of 4-HNE are its stimulation of fibrogenesis and inflammation. This indicates a potential contribution to the pathogenesis of several chronic diseases, the progression of which is supported by inflammatory reactions and characterized by fibrosis. 4-HNE may also play a role in carcinogenesis due to its ability to modulate cell proliferation through interference with the activity of cyclins and protein kinases and inhibiting the apoptotic response.

ALT Names :

4-HNE

Immunogen :

4-HNE.

Specificity :

Specific for 4-Hydroxynonenal (4-HNE).

Package Size :

200 µL

Uses :

ELISA;Western Blotting

Storage :

Maintain at -20°C in undiluted for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer.