This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Sox9 Antibody
catalog :
AB5535
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, other, western blot knockout validation, immunohistochemistry knockout validation, immunocytochemistry knockout validation
citations: 129
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; rat; 1:2000; loading ...; fig 1a
  • immunocytochemistry knockout validation; mouse; 1:2000; loading ...; fig 8c
Li J, Khankan R, Caneda C, Godoy M, Haney M, Krawczyk M, et al. Astrocyte-to-astrocyte contact and a positive feedback loop of growth factor signaling regulate astrocyte maturation. Glia. 2019;67:1571-1597 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:300; loading ...; fig 2f
  • immunohistochemistry; human; 1:300; fig 2f
Ge Y, Gomez N, Adam R, Nikolova M, Yang H, Verma A, et al. Stem Cell Lineage Infidelity Drives Wound Repair and Cancer. Cell. 2017;169:636-650.e14 pubmed publisher
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 8a
McKillop W, York E, Rubinger L, Liu T, Ossowski N, Xu K, et al. Conditional Sox9 ablation improves locomotor recovery after spinal cord injury by increasing reactive sprouting. Exp Neurol. 2016;283:1-15 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 2a
Tan J, Wollmann H, van Pelt A, Kaldis P, Messerschmidt D. Infertility-Causing Haploinsufficiency Reveals TRIM28/KAP1 Requirement in Spermatogonia. Stem Cell Reports. 2020;14:818-827 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 1m
Touahri Y, Dixit R, Kofoed R, Miloska K, Park E, Raeisossadati R, et al. Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia. Theranostics. 2020;10:2982-2999 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:2000; loading ...; fig 2c
Nomura Komoike K, Saitoh F, Fujieda H. Phosphatidylserine recognition and Rac1 activation are required for Müller glia proliferation, gliosis and phagocytosis after retinal injury. Sci Rep. 2020;10:1488 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:2000; loading ...; fig 1d
Ballabio C, Anderle M, Gianesello M, Lago C, Miele E, Cardano M, et al. Modeling medulloblastoma in vivo and with human cerebellar organoids. Nat Commun. 2020;11:583 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4g, s25b
Kim J, Fei L, Yin W, Coquenlorge S, Rao Bhatia A, Zhang X, et al. Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches. Nat Commun. 2020;11:334 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig 2d, 6d
  • western blot; human; loading ...; fig 1a
Aldaz P, Otaegi Ugartemendia M, Sáenz Antoñanzas A, Garcia Puga M, Moreno Valladares M, Flores J, et al. SOX9 promotes tumor progression through the axis BMI1-p21CIP. Sci Rep. 2020;10:357 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 6d
Xing T, Benderman L, Sabu S, Parker J, Yang J, Lu Q, et al. Tight Junction Protein Claudin-7 Is Essential for Intestinal Epithelial Stem Cell Self-Renewal and Differentiation. Cell Mol Gastroenterol Hepatol. 2020;9:641-659 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 3a
Francis R, Guo H, Streutker C, Ahmed M, Yung T, Dirks P, et al. Gastrointestinal transcription factors drive lineage-specific developmental programs in organ specification and cancer. Sci Adv. 2019;5:eaax8898 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 3f
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 1f
Quilichini E, Fabre M, Dirami T, Stedman A, De Vas M, Ozguc O, et al. Pancreatic ductal deletion of Hnf1b disrupts exocrine homeostasis, leads to pancreatitis and facilitates tumorigenesis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1d
Legrand J, Chan A, La H, Rossello F, Ankö M, Fuller Pace F, et al. DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia. Nat Commun. 2019;10:2278 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4c
Zhang J, Zhang X, Zhang Y, Zeng W, Zhao S, Liu M. Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice. Peerj. 2019;7:e6827 pubmed publisher
  • immunohistochemistry; mouse; 1:10,000; fig 2b
Reinhardt R, Gullotta F, Nusspaumer G, Unal E, Ivanek R, Zuniga A, et al. Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling. Development. 2019;146: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 3e
Ghaffari R, Di Bona K, Riley C, Richburg J. Copper transporter 1 (CTR1) expression by mouse testicular germ cells, but not Sertoli cells, is essential for functional spermatogenesis. PLoS ONE. 2019;14:e0215522 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:3500; loading ...; fig 1b
Krimpenfort P, Snoek M, Lambooij J, Song J, van der Weide R, Bhaskaran R, et al. A natural WNT signaling variant potently synergizes with Cdkn2ab loss in skin carcinogenesis. Nat Commun. 2019;10:1425 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 4a
Schulien I, Hockenjos B, Schmitt Graeff A, Perdekamp M, Follo M, Thimme R, et al. The transcription factor c-Jun/AP-1 promotes liver fibrosis during non-alcoholic steatohepatitis by regulating Osteopontin expression. Cell Death Differ. 2019;: pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1b
  • western blot; human; loading ...; fig 1a
Domenici G, Aurrekoetxea Rodríguez I, Simões B, Rábano M, Lee S, Millán J, et al. A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells. Oncogene. 2019;38:3151-3169 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 7e
Hoefert J, Bjerke G, Wang D, Yi R. The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis. J Cell Biol. 2018;217:2185-2204 pubmed publisher
  • western blot; human; fig 3j
Wu X, Dao Thi V, Huang Y, Billerbeck E, Saha D, Hoffmann H, et al. Intrinsic Immunity Shapes Viral Resistance of Stem Cells. Cell. 2018;172:423-438.e25 pubmed publisher
  • western blot; human; fig 4e
Arrizabalaga O, Moreno Cugnon L, Auzmendi Iriarte J, Aldaz P, Ibanez de Caceres I, Garros Regulez L, et al. High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response. Oncogenesis. 2017;6:401 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 3a
He H, Huang M, Sun S, Wu Y, Lin X. Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development. PLoS Genet. 2017;13:e1006992 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s12f
Rogers Z, McFarland C, Winters I, Naranjo S, Chuang C, Petrov D, et al. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nat Methods. 2017;14:737-742 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 9l
Chatzeli L, Gaete M, Tucker A. Fgf10 and Sox9 are essential for the establishment of distal progenitor cells during mouse salivary gland development. Development. 2017;144:2294-2305 pubmed publisher
  • immunohistochemistry; human; fig 10h
Haston S, Pozzi S, Carreno G, Manshaei S, Panousopoulos L, González Meljem J, et al. MAPK pathway control of stem cell proliferation and differentiation in the embryonic pituitary provides insights into the pathogenesis of papillary craniopharyngioma. Development. 2017;144:2141-2152 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 3a
Dong E, Bachleda A, Xiong Y, Osawa S, Weiss E. Reduced phosphoCREB in Müller glia during retinal degeneration in rd10 mice. Mol Vis. 2017;23:90-102 pubmed
  • other; human; loading ...; fig 6
Egunsola A, Bae Y, Jiang M, Liu D, Chen Evenson Y, Bertin T, et al. Loss of DDRGK1 modulates SOX9 ubiquitination in spondyloepimetaphyseal dysplasia. J Clin Invest. 2017;127:1475-1484 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4d
Genovese G, Carugo A, TEPPER J, Robinson F, Li L, Svelto M, et al. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017;542:362-366 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 4
Weng C, Ding M, Chang L, Ren M, Zhang H, Lu Z, et al. Ankfy1 is dispensable for neural stem/precursor cell development. Neural Regen Res. 2016;11:1804-1809 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 1a
  • western blot; mouse; 1:2000; loading ...; fig 2b
Tamamura Y, Katsube K, Mera H, Itokazu M, Wakitani S. Irx3 and Bmp2 regulate mouse mesenchymal cell chondrogenic differentiation in both a Sox9-dependent and -independent manner. J Cell Physiol. 2017;232:3317-3336 pubmed publisher
  • immunocytochemistry; mouse; 1:4000; fig 3c
  • immunohistochemistry; mouse; 1:4000; loading ...; fig 1a
Wang J, O Sullivan M, Mukherjee D, Punal V, Farsiu S, Kay J. Anatomy and spatial organization of Müller glia in mouse retina. J Comp Neurol. 2017;525:1759-1777 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 4f
Rux D, Song J, Swinehart I, Pineault K, Schlientz A, Trulik K, et al. Regionally Restricted Hox Function in Adult Bone Marrow Multipotent Mesenchymal Stem/Stromal Cells. Dev Cell. 2016;39:653-666 pubmed publisher
  • western blot; human; 1:500; loading ...
Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, et al. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4j
  • western blot; mouse; loading ...; fig 2a
Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig s6d
Pu W, Zhang H, Huang X, Tian X, He L, Wang Y, et al. Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration. Nat Commun. 2016;7:13369 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3h
Cho S, Song J, Shin J, Kim S. Neonatal disease environment limits the efficacy of retinal transplantation in the LCA8 mouse model. BMC Ophthalmol. 2016;16:193 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:5000; loading ...; fig s6b
Kikuchi I, Takahashi Kanemitsu A, Sakiyama N, Tang C, Tang P, Noda S, et al. Dephosphorylated parafibromin is a transcriptional coactivator of the Wnt/Hedgehog/Notch pathways. Nat Commun. 2016;7:12887 pubmed publisher
  • immunoprecipitation; human; fig 4
  • western blot; human; fig 1
Hong X, Liu W, Song R, Shah J, Feng X, Tsang C, et al. SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage. Nucleic Acids Res. 2016;44:8855-8869 pubmed
  • immunohistochemistry; mouse; 1:1000; fig 1
  • western blot; mouse; 1:5000; fig 1
Martin K, Pritchett J, Llewellyn J, Mullan A, Athwal V, Dobie R, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
Nakamichi R, Ito Y, Inui M, Onizuka N, Kayama T, Kataoka K, et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs. Nat Commun. 2016;7:12503 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 1d
Medrano J, Rombaut C, Simon C, Pellicer A, Goossens E. Human spermatogonial stem cells display limited proliferation in vitro under mouse spermatogonial stem cell culture conditions. Fertil Steril. 2016;106:1539-1549.e8 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 0.2 mg/ml; loading ...; fig 9f
Agrimson K, Onken J, Mitchell D, Topping T, Chiarini Garcia H, Hogarth C, et al. Characterizing the Spermatogonial Response to Retinoic Acid During the Onset of Spermatogenesis and Following Synchronization in the Neonatal Mouse Testis. Biol Reprod. 2016;95:81 pubmed
  • immunohistochemistry; mouse; 1:300
Reginensi A, Enderle L, Gregorieff A, Johnson R, Wrana J, McNeill H. A critical role for NF2 and the Hippo pathway in branching morphogenesis. Nat Commun. 2016;7:12309 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3b
Lesina M, Wörmann S, Morton J, Diakopoulos K, Korneeva O, Wimmer M, et al. RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis. J Clin Invest. 2016;126:2919-32 pubmed publisher
  • immunocytochemistry; mouse; fig s2
Iwasaki Y, Sugita S, Mandai M, Yonemura S, Onishi A, Ito S, et al. Differentiation/Purification Protocol for Retinal Pigment Epithelium from Mouse Induced Pluripotent Stem Cells as a Research Tool. PLoS ONE. 2016;11:e0158282 pubmed publisher
  • western blot; human; loading ...; fig 5A
Duru N, Gernapudi R, Lo P, Yao Y, Wolfson B, Zhang Y, et al. Characterization of the CD49f+/CD44+/CD24- single-cell derived stem cell population in basal-like DCIS cells. Oncotarget. 2016;7:47511-47525 pubmed publisher
  • immunohistochemistry - frozen section; mouse; tbl 1
PACKARD A, Lin B, Schwob J. Sox2 and Pax6 Play Counteracting Roles in Regulating Neurogenesis within the Murine Olfactory Epithelium. PLoS ONE. 2016;11:e0155167 pubmed publisher
  • immunocytochemistry; human; fig 1
  • immunohistochemistry; human; fig 1
  • western blot; human; fig 1
Leung C, Mak W, Kai A, Chan K, Lee T, Ng I, et al. Sox9 confers stemness properties in hepatocellular carcinoma through Frizzled-7 mediated Wnt/?-catenin signaling. Oncotarget. 2016;7:29371-86 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 2
Balakrishnan A, Stykel M, Touahri Y, Stratton J, Biernaskie J, Schuurmans C. Temporal Analysis of Gene Expression in the Murine Schwann Cell Lineage and the Acutely Injured Postnatal Nerve. PLoS ONE. 2016;11:e0153256 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 1
Seidel P, Remus M, Delacher M, Grigaravicius P, Reuss D, Frappart L, et al. Epidermal Nbn deletion causes premature hair loss and a phenotype resembling psoriasiform dermatitis. Oncotarget. 2016;7:23006-18 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; fig 1d
  • western blot; human; 1:1000; fig s11
Nagao M, Ogata T, Sawada Y, Gotoh Y. Zbtb20 promotes astrocytogenesis during neocortical development. Nat Commun. 2016;7:11102 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2
Nuñez O, Román A, Johnson S, Inoue Y, Hirose M, Casanova Ã, et al. Study of breast cancer incidence in patients of lymphangioleiomyomatosis. Breast Cancer Res Treat. 2016;156:195-201 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig s5
Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay H, Yang D, et al. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell. 2016;18:797-808 pubmed publisher
  • immunocytochemistry; human; 1:100; fig s1
  • immunohistochemistry; human; 1:100; fig 6
Yao C, Sun M, Yuan Q, Niu M, Chen Z, Hou J, et al. MiRNA-133b promotes the proliferation of human Sertoli cells through targeting GLI3. Oncotarget. 2016;7:2201-19 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 2
Gho C, Schomann T, de Groot S, Frijns J, Rivolta M, Neumann M, et al. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery. Cytotechnology. 2016;68:1849-58 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5d
Trierweiler C, Hockenjos B, Zatloukal K, Thimme R, Blum H, Wagner E, et al. The transcription factor c-JUN/AP-1 promotes HBV-related liver tumorigenesis in mice. Cell Death Differ. 2016;23:576-82 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3a
  • western blot; human; loading ...; fig 4e
Luanpitpong S, Li J, Manke A, Brundage K, Ellis E, McLaughlin S, et al. SLUG is required for SOX9 stabilization and functions to promote cancer stem cells and metastasis in human lung carcinoma. Oncogene. 2016;35:2824-33 pubmed publisher
Stewart M, Mattiske D, Pask A. Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line. BMC Mol Cell Biol. 2020;21:66 pubmed publisher
Rohländer M, Otzen H, Rode K, Jung K, Schmicke M, Harborth T, et al. Histological Comparison of Testicular Needle Biopsy and En Bloc Samples in Abattoir Calves. Animals (Basel). 2020;10: pubmed publisher
Jaiswal P, Aljebali L, Gaumond M, Oh C, Yasuda H, Moffatt P. Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9. Sci Rep. 2020;10:7790 pubmed publisher
Weber C, Zhou Y, Lee J, Looger L, Qian G, Ge C, et al. Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. Science. 2020;368:303-306 pubmed publisher
Voronkova M, Rojanasakul L, Kiratipaiboon C, Rojanasakul Y. The SOX9-Aldehyde Dehydrogenase Axis Determines Resistance to Chemotherapy in Non-Small-Cell Lung Cancer. Mol Cell Biol. 2020;40: pubmed publisher
Patel S, Hartley R, Wei X, Furnish R, Escobar Riquelme F, Bear H, et al. Generation of diffuse intrinsic pontine glioma mouse models by brainstem-targeted in utero electroporation. Neuro Oncol. 2020;22:381-392 pubmed publisher
Arai H, Sato F, Yamamoto T, Woltjen K, Kiyonari H, Yoshimoto Y, et al. Metalloprotease-Dependent Attenuation of BMP Signaling Restricts Cardiac Neural Crest Cell Fate. Cell Rep. 2019;29:603-616.e5 pubmed publisher
Atsuta Y, Tomizawa R, Levin M, Tabin C. L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. Proc Natl Acad Sci U S A. 2019;116:21592-21601 pubmed publisher
Rojo R, Raper A, Ozdemir D, Lefèvre L, Grabert K, Wollscheid Lengeling E, et al. Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations. Nat Commun. 2019;10:3215 pubmed publisher
Pineault K, Song J, Kozloff K, Lucas D, Wellik D. Hox11 expressing regional skeletal stem cells are progenitors for osteoblasts, chondrocytes and adipocytes throughout life. Nat Commun. 2019;10:3168 pubmed publisher
Perkhofer L, Engler M, Gout J, Arnold F, Morawe M, Breunig M, et al. Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Stem Cells Int. 2019;2019:2079742 pubmed publisher
Ortiz Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, et al. Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members. Neuron. 2019;102:159-172.e7 pubmed publisher
Korecki A, Hickmott J, Lam S, Dreolini L, Mathelier A, Baker O, et al. Twenty-Seven Tamoxifen-Inducible iCre-Driver Mouse Strains for Eye and Brain, Including Seventeen Carrying a New Inducible-First Constitutive-Ready Allele. Genetics. 2019;211:1155-1177 pubmed publisher
Ideno N, Yamaguchi H, Okumura T, Huang J, Brun M, Ho M, et al. A pipeline for rapidly generating genetically engineered mouse models of pancreatic cancer using in vivo CRISPR-Cas9-mediated somatic recombination. Lab Invest. 2019;: pubmed publisher
Yang X, Liang R, Liu C, Liu J, Cheung M, Liu X, et al. SOX9 is a dose-dependent metastatic fate determinant in melanoma. J Exp Clin Cancer Res. 2019;38:17 pubmed publisher
Young C, Baker R, Howlett C, Hryciw T, Herman J, Higgs D, et al. The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice. Cell Mol Gastroenterol Hepatol. 2019;7:93-113 pubmed publisher
Croft B, Ohnesorg T, Hewitt J, Bowles J, Quinn A, Tan J, et al. Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9. Nat Commun. 2018;9:5319 pubmed publisher
Yuan W, Pepe Mooney B, Galli G, Dill M, Huang H, Hao M, et al. NUAK2 is a critical YAP target in liver cancer. Nat Commun. 2018;9:4834 pubmed publisher
Omer Javed A, Li Y, Muffat J, Su K, Cohen M, Lungjangwa T, et al. Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype. Cell Rep. 2018;25:368-382.e5 pubmed publisher
Yan J, Huang W, Huang X, Xiang W, Ye C, Liu J. A negative feedback loop between long noncoding RNA NBAT1 and Sox9 inhibits the malignant progression of gastric cancer cells. Biosci Rep. 2018;38: pubmed publisher
Stringer J, Forster S, Qu Z, Prokopuk L, O Bryan M, Gardner D, et al. Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance. BMC Biol. 2018;16:104 pubmed publisher
El Sebae G, Malatos J, Cone M, Rhee S, Angelo J, Mager J, et al. Single-cell murine genetic fate mapping reveals bipotential hepatoblasts and novel multi-organ endoderm progenitors. Development. 2018;145: pubmed publisher
Holmes G, O Rourke C, Motch Perrine S, Lu N, van Bakel H, Richtsmeier J, et al. Midface and upper airway dysgenesis in FGFR2-related craniosynostosis involves multiple tissue-specific and cell cycle effects. Development. 2018;145: pubmed publisher
Zanconato F, Battilana G, Forcato M, Filippi L, Azzolin L, Manfrin A, et al. Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4. Nat Med. 2018;24:1599-1610 pubmed publisher
Tsuji Hosokawa A, Kashimada K, Kato T, Ogawa Y, Nomura R, Takasawa K, et al. Peptidyl arginine deiminase 2 (Padi2) is expressed in Sertoli cells in a specific manner and regulated by SOX9 during testicular development. Sci Rep. 2018;8:13263 pubmed publisher
Lewis P, Su J, Yan M, Meng F, Glaser S, ALPINI G, et al. Complex bile duct network formation within liver decellularized extracellular matrix hydrogels. Sci Rep. 2018;8:12220 pubmed publisher
Ramond C, Beydag Tasöz B, Azad A, van de Bunt M, Petersen M, Beer N, et al. Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling. Development. 2018;145: pubmed publisher
Wang C, Tan Z, Niu B, Tsang K, Tai A, Chan W, et al. Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia. elife. 2018;7: pubmed publisher
Liu C, Angelozzi M, Haseeb A, Lefebvre V. SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis. Development. 2018;145: pubmed publisher
Livshits G, Alonso Curbelo D, Morris J, Koche R, Saborowski M, Wilkinson J, et al. Arid1a restrains Kras-dependent changes in acinar cell identity. elife. 2018;7: pubmed publisher
Iezaki T, Horie T, Fukasawa K, Kitabatake M, Nakamura Y, Park G, et al. Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis. Stem Cell Reports. 2018;11:228-241 pubmed publisher
Liu E, Martins J, Zhang W, Demay M. Molecular analysis of enthesopathy in a mouse model of hypophosphatemic rickets. Development. 2018;145: pubmed publisher
Perekatt A, Shah P, Cheung S, Jariwala N, Wu A, Gandhi V, et al. SMAD4 Suppresses WNT-Driven Dedifferentiation and Oncogenesis in the Differentiated Gut Epithelium. Cancer Res. 2018;78:4878-4890 pubmed publisher
Piacentino M, Bronner M. Intracellular attenuation of BMP signaling via CKIP-1/Smurf1 is essential during neural crest induction. PLoS Biol. 2018;16:e2004425 pubmed publisher
Cai Q, Fan Q, Buechlein A, Miller D, Nephew K, Liu S, et al. Changes in mRNA/protein expression and signaling pathways in in vivo passaged mouse ovarian cancer cells. PLoS ONE. 2018;13:e0197404 pubmed publisher
Jauregui E, Mitchell D, Topping T, Hogarth C, Griswold M. Retinoic acid receptor signaling is necessary in steroidogenic cells for normal spermatogenesis and epididymal function. Development. 2018;145: pubmed publisher
Tsushima H, Tang Y, Puviindran V, Hsu S, Nadesan P, Yu C, et al. Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018;145: pubmed publisher
Biehl M, Kaylan K, Thompson R, Gonzalez R, Weis K, Underhill G, et al. Cellular fate decisions in the developing female anteroventral periventricular nucleus are regulated by canonical Notch signaling. Dev Biol. 2018;442:87-100 pubmed publisher
Bai S, Fu K, Yin H, Cui Y, Yue Q, Li W, et al. Sox30 initiates transcription of haploid genes during late meiosis and spermiogenesis in mouse testes. Development. 2018;145: pubmed publisher
Hurtado A, Real F, Palomino R, Carmona F, Burgos M, Jimenez R, et al. Sertoli cell-specific ablation of miR-17-92 cluster significantly alters whole testis transcriptome without apparent phenotypic effects. PLoS ONE. 2018;13:e0197685 pubmed publisher
Jiang H, Gao Q, Zheng W, Yin S, Wang L, Zhong L, et al. MOF influences meiotic expansion of H2AX phosphorylation and spermatogenesis in mice. PLoS Genet. 2018;14:e1007300 pubmed publisher
Sakagami N, Matsushita Y, Syklawer Howle S, Kronenberg H, Ono W, Ono N. Msx2 Marks Spatially Restricted Populations of Mesenchymal Precursors. J Dent Res. 2018;97:1260-1267 pubmed publisher
Tosches M, Yamawaki T, Naumann R, Jacobi A, Tushev G, Laurent G. Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles. Science. 2018;360:881-888 pubmed publisher
Shoshkes Carmel M, WANG Y, Wangensteen K, Tóth B, Kondo A, Massasa E, et al. Subepithelial telocytes are an important source of Wnts that supports intestinal crypts. Nature. 2018;557:242-246 pubmed publisher
Imaimatsu K, Fujii W, Hiramatsu R, Miura K, Kurohmaru M, Kanai Y. CRISPR/Cas9-mediated knock-in of the murine Y chromosomal Sry gene. J Reprod Dev. 2018;64:283-287 pubmed publisher
Lees Shepard J, Yamamoto M, Biswas A, Stoessel S, Nicholas S, Cogswell C, et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun. 2018;9:471 pubmed publisher
Elsaeidi F, MacPherson P, Mills E, Jui J, Flannery J, Goldman D. Notch Suppression Collaborates with Ascl1 and Lin28 to Unleash a Regenerative Response in Fish Retina, But Not in Mice. J Neurosci. 2018;38:2246-2261 pubmed publisher
Nickells R, Schmitt H, Maes M, Schlamp C. AAV2-Mediated Transduction of the Mouse Retina After Optic Nerve Injury. Invest Ophthalmol Vis Sci. 2017;58:6091-6104 pubmed publisher
Barter M, Gomez R, Hyatt S, Cheung K, Skelton A, Xu Y, et al. The long non-coding RNA ROCR contributes to SOX9 expression and chondrogenic differentiation of human mesenchymal stem cells. Development. 2017;144:4510-4521 pubmed publisher
Fonseca B, Couly G, Dupin E. Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo. BMC Dev Biol. 2017;17:13 pubmed publisher
Inui M, Tamano M, Kato T, Takada S. CRISPR/Cas9-mediated simultaneous knockout of Dmrt1 and Dmrt3 does not recapitulate the 46,XY gonadal dysgenesis observed in 9p24.3 deletion patients. Biochem Biophys Rep. 2017;9:238-244 pubmed publisher
Li Y, Zhang L, Hu Y, Han F, Qin Y, Chen M, et al. β-Catenin directs the transformation of testis Sertoli cells to ovarian granulosa-like cells by inducing Foxl2 expression. J Biol Chem. 2017;292:17577-17586 pubmed publisher
Casoni F, Croci L, Bosone C, D Ambrosio R, Badaloni A, Gaudesi D, et al. Zfp423/ZNF423 regulates cell cycle progression, the mode of cell division and the DNA-damage response in Purkinje neuron progenitors. Development. 2017;144:3686-3697 pubmed publisher
Lo R, Leung C, Chok K, Ng I. Variation of stemness markers expression in tumor nodules from synchronous multi-focal hepatocellular carcinoma - an immunohistochemical study. Diagn Pathol. 2017;12:56 pubmed publisher
Jeselsohn R, Cornwell M, Pun M, Buchwalter G, Nguyen M, Bango C, et al. Embryonic transcription factor SOX9 drives breast cancer endocrine resistance. Proc Natl Acad Sci U S A. 2017;114:E4482-E4491 pubmed publisher
Wang Y, Huang X, He L, Pu W, Li Y, Liu Q, et al. Genetic tracing of hepatocytes in liver homeostasis, injury, and regeneration. J Biol Chem. 2017;292:8594-8604 pubmed publisher
Ruthig V, Nielsen T, Riel J, Yamauchi Y, Ortega E, Salvador Q, et al. Testicular abnormalities in mice with Y chromosome deficiencies. Biol Reprod. 2017;96:694-706 pubmed publisher
Minkina A, Lindeman R, Gearhart M, Chassot A, Chaboissier M, Ghyselinck N, et al. Retinoic acid signaling is dispensable for somatic development and function in the mammalian ovary. Dev Biol. 2017;424:208-220 pubmed publisher
Higaki S, Shimada M, Kawamoto K, Todo T, Kawasaki T, Tooyama I, et al. In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens). Sci Rep. 2017;7:42852 pubmed publisher
Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, et al. BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes. Nat Commun. 2017;8:13824 pubmed publisher
Wang Y, Chiang H, Huang Y, Hsu C, Yang P, Juan H, et al. A link between adipogenesis and innate immunity: RNase-L promotes 3T3-L1 adipogenesis by destabilizing Pref-1 mRNA. Cell Death Dis. 2016;7:e2458 pubmed publisher
Ul Quraish R, Sudou N, Nomura Komoike K, Sato F, Fujieda H. p27KIP1 loss promotes proliferation and phagocytosis but prevents epithelial-mesenchymal transition in RPE cells after photoreceptor damage. Mol Vis. 2016;22:1103-1121 pubmed
Rebourcet D, Wu J, Cruickshanks L, Smith S, Milne L, Fernando A, et al. Sertoli Cells Modulate Testicular Vascular Network Development, Structure, and Function to Influence Circulating Testosterone Concentrations in Adult Male Mice. Endocrinology. 2016;157:2479-88 pubmed publisher
Cappato S, Tonachini L, Giacopelli F, Tirone M, Galietta L, Sormani M, et al. High-throughput screening for modulators of ACVR1 transcription: discovery of potential therapeutics for fibrodysplasia ossificans progressiva. Dis Model Mech. 2016;9:685-96 pubmed publisher
Del Debbio C, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L, et al. Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1. PLoS ONE. 2016;11:e0152025 pubmed publisher
Laurie L, Kokubo H, Nakamura M, Saga Y, Funato N. The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification. PLoS ONE. 2016;11:e0150263 pubmed publisher
McDermott B, Ellis S, Bou Gharios G, Clegg P, Tew S. RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes. Osteoarthritis Cartilage. 2016;24:1263-73 pubmed publisher
Welborn J, Davis M, Ebers S, Stodden G, Hayashi K, Cheatwood J, et al. Rhox8 Ablation in the Sertoli Cells Using a Tissue-Specific RNAi Approach Results in Impaired Male Fertility in Mice. Biol Reprod. 2015;93:8 pubmed publisher
Prakash A, Udager A, Saenz D, Gumucio D. Roles for Nkx2-5 and Gata3 in the ontogeny of the murine smooth muscle gastric ligaments. Am J Physiol Gastrointest Liver Physiol. 2014;307:G430-6 pubmed publisher
Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, et al. LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3. BMC Biol. 2014;12:25 pubmed publisher
product information
Catalog Number :
AB5535
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-Sox9 Antibody
Product Type :
Antibodies
Clonality :
Polyclonal Antibody
Gene ID :
P48436
Host Name :
Rabbit
Antigen :
Sox9
Conjugate :
Affinity Purified
Product Description :
Anti-Sox9 Antibody
Cross Reactivity :
Human;Mouse;Rat
Background :
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
Immunogen :
Synthetic peptide from human Sox9.
Specificity :
Recognizes Sox9.
Package Size :
100 µg
Uses :
Immunohistochemistry;Western Blotting
Storage :
Stable for 6 months at 2-8°C in undiluted aliquots from date of receipt.
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

Hundreds of New Antibodies in the areas of:
  • • Cancer
  • • Nuclear Signaling
  • • Apoptosis
  • • Cardiovascular Disease
  • • Developmental Biology
  • • Metabolic Disease
  • • Neurodegenerative Disease
  • • Cell Biology
View all the new antibodies at www.emdmillipore.com.