Calcium Channel Antibody, Voltage Gated α 1C | EMD Millipore AB5156 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Calcium Channel Antibody, Voltage Gated α 1C

catalog :

AB5156

quantity :

200 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:150; loading ...; fig 2a	Panagiotakos G, Haveles C, Arjun A, Petrova R, Rana A, Portmann T, et al. Aberrant calcium channel splicing drives defects in cortical differentiation in Timothy syndrome. elife. 2019;8: pubmed publisher
immunohistochemistry; mouse; 1:100; loading ...; tbl 1	Barzan R, Pfeiffer F, Kukley M. N- and L-Type Voltage-Gated Calcium Channels Mediate Fast Calcium Transients in Axonal Shafts of Mouse Peripheral Nerve. Front Cell Neurosci. 2016;10:135 pubmed publisher
	Christie M, Romano T, Murphy R, Posterino G. The effect of intrauterine growth restriction on Ca2+ -activated force and contractile protein expression in the mesenteric artery of adult (6-month-old) male and female Wistar-Kyoto rats. Physiol Rep. 2018;6:e13954 pubmed publisher

product information

Catalog Number :

AB5156

Subcategory :

Neuroscience

Product Name :

Anti-Calcium Channel Antibody, Voltage Gated α 1C

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13936

Host Name :

Rabbit

Antigen :

Calcium Channel

Conjugate :

Affinity Purified

Product Description :

Anti-Calcium Channel Antibody, Voltage Gated α 1C

Cross Reactivity :

Human;Mouse;Rat;Rabbit

Background :

Voltage-sensitive calcium channels (vscc) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1c gives rise to l-type calcium currents. Long-lasting (l-type) calcium channels belong to the "high-voltage activated" (hva) group. They are blocked by dihydropyridines (dhp), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin- gvia (omega-ctx-gvia) and omega-agatoxin-IVA (omega-aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. The various isoforms display marked differences in the sensitivity to dhp compounds (Swiss Prot).

ALT Names :

L-type

Immunogen :

Purified peptide (C)TTKI NMDDL QPSEN EDKS (CNC1) from 848-865 of alpha 1C subunit of rat brain voltage-gated calcium channel (Accession number P22002). Epitope location is in the intracellular loop between domains II and III.

Specificity :

Recognizes alpha 1C subunit (both LMW and HMW forms) of voltage-gated calcium channel. Does not cross react with any other calcium channel antigens tested so far. Guinea pig (17/18 residues identical); human and rabbit (16/18 residues identical).

Package Size :

200 μL

Uses :

Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Maintain lyophilized material at -20°C for up to 12 months. After reconstitution add glycerol (ASC grade or better) at a ratio of 1:1 and maintain at -20°C for up to 6 months. Avoid repeated freeze/thaw cycles.