Dopamine D2 Receptor Antibody | EMD Millipore AB5084P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dopamine D2 Receptor Antibody

catalog :

AB5084P

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, flow cytometry, western blot knockout validation, immunohistochemistry knockout validation

citations: 22

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:50; loading ...; fig 2e western blot knockout validation; mouse; 1:250; loading ...; fig 1c	Stojanovic T, Orlova M, Sialana F, HÃ¶ger H, Stuchlík S, Milenkovic I, et al. Validation of dopamine receptor DRD1 and DRD2 antibodies using receptor deficient mice. Amino Acids. 2017;49:1101-1109 pubmed publisher
immunohistochemistry; mouse; 1:200; loading ...; fig s5d	Eom T, Han S, Kim J, Blundon J, Wang Y, Yu J, et al. Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice. Nat Commun. 2020;11:912 pubmed publisher
flow cytometry; rat; 1:200; loading ...; fig 1l immunohistochemistry; rat; 1:200; loading ...; fig 1k	Yu Q, Liu Y, Zhu Y, Wang Y, Li Q, Yin D. Genetic labeling reveals temporal and spatial expression pattern of D2 dopamine receptor in rat forebrain. Brain Struct Funct. 2019;224:1035-1049 pubmed publisher
western blot; mouse; 1:1000; fig s5a	Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
western blot; rat; loading ...; fig 5c	ConceiÃ§Ã£o E, Carvalho J, ManhÃ£es A, Guarda D, Figueiredo M, Quitete F, et al. Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation. J Neuroendocrinol. 2016;28: pubmed publisher
western blot; rat; 1:500; loading ...; fig 2	Romano López A, Méndez Díaz M, García F, Regalado Santiago C, Ruiz Contreras A, Prospero Garcia O. Maternal separation and early stress cause long-lasting effects on dopaminergic and endocannabinergic systems and alters dendritic morphology in the nucleus accumbens and frontal cortex in rats. Dev Neurobiol. 2016;76:819-31 pubmed publisher
western blot; rat; 1:1000	Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016;41:811-21 pubmed publisher
western blot; rat; 1:500	GarcÃa PÃ©rez D, NÃºÃ±ez C, Laorden M, MilanÃ©s M. Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal. Addict Biol. 2016;21:374-86 pubmed publisher
	Hasbi A, Nguyen T, Rahal H, Manduca J, Miksys S, Tyndale R, et al. Sex difference in dopamine D1-D2 receptor complex expression and signaling affects depression- and anxiety-like behaviors. Biol Sex Differ. 2020;11:8 pubmed publisher
	Wang J, Li Y, Luo P, Chen Y, Xi Q, Wu H, et al. Oral supplementation with ginseng polysaccharide promotes food intake in mice. Brain Behav. 2019;9:e01340 pubmed publisher
	Pristerá A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, et al. Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration. Proc Natl Acad Sci U S A. 2019;116:3817-3826 pubmed publisher
	Sellnow R, Newman J, Chambers N, West A, Steece Collier K, Sandoval I, et al. Regulation of dopamine neurotransmission from serotonergic neurons by ectopic expression of the dopamine D2 autoreceptor blocks levodopa-induced dyskinesia. Acta Neuropathol Commun. 2019;7:8 pubmed publisher
	Huang Z, Hoffman C, Chelette B, Thiebaud N, Fadool D. Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice. Front Behav Neurosci. 2018;12:49 pubmed publisher
	Navarro G, Cordomi A, Casadó Anguera V, Moreno E, Cai N, Cortés A, et al. Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase. Nat Commun. 2018;9:1242 pubmed publisher
	Xu S, Tu S, Gao J, Liu J, Guo Z, Zhang J, et al. Protective and restorative effects of the traditional Chinese medicine Jitai tablet against methamphetamine-induced dopaminergic neurotoxicity. BMC Complement Altern Med. 2018;18:76 pubmed publisher
	Wang X, Villar V, Tiu A, Upadhyay K, Cuevas S. Dopamine D2 receptor upregulates leptin and IL-6 in adipocytes. J Lipid Res. 2018;59:607-614 pubmed publisher
	Hasbi A, Perreault M, Shen M, Fan T, Nguyen T, Alijaniaram M, et al. Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB. Front Pharmacol. 2017;8:924 pubmed publisher
	Schrantee A, Tremoleda J, Wylezinska Arridge M, Bouet V, Hesseling P, Meerhoff G, et al. Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate. PLoS ONE. 2017;12:e0172776 pubmed publisher
	Gracia Rubio I, Martínez Laorden E, Moscoso Castro M, Milanes M, Laorden M, Valverde O. Maternal Separation Impairs Cocaine-Induced Behavioural Sensitization in Adolescent Mice. PLoS ONE. 2016;11:e0167483 pubmed publisher
	Ip C, Isaias I, Kusche Tekin B, Klein D, Groh J, O Leary A, et al. Tor1a+/- mice develop dystonia-like movements via a striatal dopaminergic dysregulation triggered by peripheral nerve injury. Acta Neuropathol Commun. 2016;4:108 pubmed
	Rico A, Dopeso Reyes I, MartÃnez Pinilla E, Sucunza D, Pignataro D, Roda E, et al. Neurochemical evidence supporting dopamine D1-D2 receptor heteromers in the striatum of the long-tailed macaque: changes following dopaminergic manipulation. Brain Struct Funct. 2017;222:1767-1784 pubmed publisher
	Ortega Legaspi J, de Gortari P, Garduño Gutiérrez R, Amaya M, León Olea M, Coffeen U, et al. Expression of the dopaminergic D1 and D2 receptors in the anterior cingulate cortex in a model of neuropathic pain. Mol Pain. 2011;7:97 pubmed publisher

product information

Catalog Number :

AB5084P

Subcategory :

Neuroscience

Product Name :

Anti-Dopamine D2 Receptor Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P14416

Host Name :

Rabbit

Antigen :

Dopamine D2 Receptor

Conjugate :

Affinity Purified

Product Description :

Anti-Dopamine D2 Receptor Antibody

Cross Reactivity :

Human;Mouse;Rat;Monkey

Background :

The Dopamine D2 Receptor is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. 2 isoforms are reported for the D2 Dopamine Receptor, Isoform 1 and isoform 2 which are expressed in the pituitary and brain; Isoform 1 is expressed seven times more than isoform 2 in the caudate nucleus.

ALT Names :

Dopamine D2 receptor

Immunogen :

A 28 amino acid peptide sequence from the human D2 receptor within the cytoplasmic loop #3.

Specificity :

Specific for Dopamine Receptor D2 short and long form. Dopamine D2 receptor is known to exist in the short (D2S) and the long (D2L) forms that are encoded by splice variants of a single gene and differ only by the presence of an additional 29 amino acid in the intracellular, cytoplasmic loop 3 (1). D2L receptor is a 446 aa, G-protein coupled and transmembrane receptor protein (2). The immunogen peptide shows no significant homology with other dopamine receptors (D1 and D3-D5).

Package Size :

50 µg

Uses :

ELISA;Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.