Beta-Amyloid 1-42 Antibody | EMD Millipore AB5078P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Beta-Amyloid 1-42 Antibody

catalog :

AB5078P

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

citations: 13

Published Application/Species/Sample/Dilution	Reference
ELISA; mouse; loading ...; fig 6a	Qin X, Wang Y, Paudel H. Early Growth Response 1 (Egr-1) Is a Transcriptional Activator of ?-Secretase 1 (BACE-1) in the Brain. J Biol Chem. 2016;291:22276-22287 pubmed
immunohistochemistry; mouse; 1:200; fig 4	Velázquez R, Shaw D, Caccamo A, Oddo S. Pim1 inhibition as a novel therapeutic strategy for Alzheimer's disease. Mol Neurodegener. 2016;11:52 pubmed publisher
western blot; human; fig 3	Huang Y, Lin C, Liao H, Liu C, Chen Y, Chiu W, et al. Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling. Neuroscience. 2016;328:201-9 pubmed publisher
immunohistochemistry; human; tbl 1	Montine T, Monsell S, Beach T, Bigio E, Bu Y, Cairns N, et al. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016;12:164-169 pubmed publisher
	Cai C, Yang C, Zhuang X, Yuan N, Wu M, Tan J, et al. NRBF2 is a RAB7 effector required for autophagosome maturation and mediates the association of APP-CTFs with active form of RAB7 for degradation. Autophagy. 2020;:1-19 pubmed publisher
	Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher
	Belfiore R, Rodin A, Ferreira E, Velázquez R, Branca C, Caccamo A, et al. Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice. Aging Cell. 2019;18:e12873 pubmed publisher
	Magaki S, Tang Z, Tung S, Williams C, Lo D, Yong W, et al. The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier. Neurobiol Aging. 2018;70:70-77 pubmed publisher
	Sorrentino V, Romani M, Mouchiroud L, Beck J, Zhang H, D Amico D, et al. Enhancing mitochondrial proteostasis reduces amyloid-? proteotoxicity. Nature. 2017;552:187-193 pubmed publisher
	Branca C, Shaw D, Belfiore R, Gokhale V, Shaw A, Foley C, et al. Dyrk1 inhibition improves Alzheimer's disease-like pathology. Aging Cell. 2017;16:1146-1154 pubmed publisher
	Wang H, Trocme Thibierge C, Stucky A, Shah S, Kvasic J, Khan A, et al. Increased Aβ42-α7-like nicotinic acetylcholine receptor complex level in lymphocytes is associated with apolipoprotein E4-driven Alzheimer's disease pathogenesis. Alzheimers Res Ther. 2017;9:54 pubmed publisher
	Bosch MoratÃ³ M, Iriondo C, Guivernau B, Valls Comamala V, Vidal N, OlivÃ© M, et al. Increased amyloid Î²-peptide uptake in skeletal muscle is induced by hyposialylation and may account for apoptosis in GNE myopathy. Oncotarget. 2016;7:13354-71 pubmed publisher
	Nathan C, Calingasan N, Nezezon J, Ding A, Lucia M, La Perle K, et al. Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase. J Exp Med. 2005;202:1163-9 pubmed

product information

Catalog Number :

AB5078P

Subcategory :

Neuroscience

Product Name :

Anti-Beta-Amyloid 1-42 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05067

Host Name :

Rabbit

Antigen :

Beta-Amyloid 1-42

Conjugate :

Affinity Purified

Product Description :

Anti-Beta-Amyloid 1-42 Antibody

Cross Reactivity :

Chicken;Human;Mouse

Background :

The cerebral and vascular plaques associated with Alzheimer's disease (AD) are mainly composed of amyloid beta peptides (Ab). Ab is derived from cleavage of the amyloid precursor protein (APP) and varies in length from 39 to 43 amino acids. Ab [1-40], Ab [1-42], and Ab [1-43] peptides result from cleavage of APP after residues 40, 42, and 43, respectively. The cleavage takes place by gamma-secretase during the last APP processing step. Ab [1-40], [1-42] and [1-43] peptides are major constituents of the plaques and tangles that occur in AD. Ab antibodies and peptides have been developed as tools for elucidating the biology of AD.

Immunogen :

A six amino acid peptide sequence from the C-terminal of human beta-amyloid 1-42.

Specificity :

Recognizes beta-amyloid 1-42. Antibody does not show appreciable reactivity with beta amyloid 1-40 as detected by ELISA. One of the most important and initial steps which causes loss of memory and cognition in Alzheimer’s Disease (AD) involves proteolytic cleavage of amyloid precursor protein (APP, chromosome 21) releasing short 40, 42 & 43 amino acid peptides (beta amyloid 1-40, 1-42 and 1-43). Polymerization of beta-amyloid and subsequent neuronal deposit (amyloid) leads to the degeneration of neurons involved in memory and cognition.

Package Size :

50 µg

Uses :

ELISA;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.