Synuclein α Antibody | EMD Millipore AB5038P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Synuclein α Antibody

catalog :

AB5038P

quantity :

20 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; loading ...; fig 3e	Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, et al. Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice. Sci Rep. 2018;8:2813 pubmed publisher
	Rusconi R, Ulusoy A, Aboutalebi H, Di Monte D. Long-lasting pathological consequences of overexpression-induced α-synuclein spreading in the rat brain. Aging Cell. 2018;17: pubmed publisher
	Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, et al. Brain-derived exosomes from dementia with Lewy bodies propagate Î±-synuclein pathology. Acta Neuropathol Commun. 2017;5:46 pubmed publisher

product information

Catalog Number :

AB5038P

Subcategory :

Neuroscience

Product Name :

Anti-Synuclein α Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P37840

Host Name :

Rabbit

Antigen :

Synuclein α

Conjugate :

Affinity Purified

Product Description :

Anti-Synuclein α Antibody

Cross Reactivity :

Human;Rat

Background :

alpha -Synuclein is a small (140-amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). alpha -Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including alpha-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).

Immunogen :

Human alpha-synuclein residues 111-131 coupled to KLH. The peptide sequence is N-GILEDMPVDPDNEAYEMPSEEC-C. This peptide is available for use in blocking studies (Cat. No. AG239).

Specificity :

Recognizes Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with beta-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.

Package Size :

20 μg

Uses :

Immunohistochemistry (Paraffin);Western Blotting

Storage :

Maintain at -20 to -70°C in undiluted aliquots for up to 12 months after date of receipt. After reconstitution maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles. Glycerol (1:1) can be added for additional stability.