Synuclein α Antibody | EMD Millipore AB5038 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Synuclein α Antibody

catalog :

AB5038

quantity :

50 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:1000	Westbroek W, Nguyen M, Siebert M, Lindstrom T, Burnett R, Aflaki E, et al. A new glucocerebrosidase-deficient neuronal cell model provides a tool to probe pathophysiology and therapeutics for Gaucher disease. Dis Model Mech. 2016;9:769-78 pubmed publisher
	Cronin Furman E, Barber Singh J, Bergquist K, Yagi T, Trimmer P. Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson's Disease. Biomolecules. 2019;9: pubmed publisher
	Magaki S, Tang Z, Tung S, Williams C, Lo D, Yong W, et al. The effects of cerebral amyloid angiopathy on integrity of the blood-brain barrier. Neurobiol Aging. 2018;70:70-77 pubmed publisher
	Regensburger M, Schreglmann S, Stoll S, Rockenstein E, Loskarn S, Xiang W, et al. Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. Brain Struct Funct. 2018;223:1357-1368 pubmed publisher
	Sarafian T, Littlejohn K, Yuan S, Fernandez C, Cilluffo M, Koo B, et al. Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated ?-synuclein. J Neurosci Res. 2017;95:1871-1887 pubmed publisher
	Mo M, Xiao Y, Huang S, Cen L, Chen X, Zhang L, et al. MicroRNA expressing profiles in A53T mutant alpha-synuclein transgenic mice and Parkinsonian. Oncotarget. 2017;8:15-28 pubmed publisher

product information

Catalog Number :

AB5038

Subcategory :

Neuroscience

Product Name :

Anti-Synuclein α Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P37840

Host Name :

Rabbit

Antigen :

Synuclein α

Conjugate :

Serum

Product Description :

Anti-Synuclein α Antibody

Cross Reactivity :

Human;Rat

Background :

alpha-Synuclein is a small (140 amino acid) cytoplasmic protein of unclear function that is enriched in presynaptic terminals and is the precursor protein of a nonamyloid beta component of senile plaques in Alzeheimer's Disease (AD). α-Synuclein is located predominantly in the presynaptic nerve terminals in the brain but is also found in low concentrations in all tissues except liver. Recent studies have shown that abnormal aggregation and accumulation of synaptic proteins, including α-Synuclein might be associated with plaque formation in AD and seems to be a major component of Lewy bodies in dementia with Lewy bodies (DLB). It has also been identified in the Glial Cytoplasmic Inclusions (GCIs) found in Multiple System Atrophy (MSA).

ALT Names :

alpha-synuclein;Alpha-synuclein

Immunogen :

Human alpha-synuclein residue 111-131 coupled to KLH.

Specificity :

Alpha-synuclein. The immunizing peptide was chosen to reduce cross-reactivity of AB5038 with β-synuclein to a minimum. Immunohistochemical and Western blot analysis of human brain indicates a high level of specificity.

Package Size :

50 µL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.