Neural Cell Adhesion Molecule Antibody | EMD Millipore AB5032 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neural Cell Adhesion Molecule Antibody

catalog :

AB5032

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 4s1a	Laurin M, Gomez N, Levorse J, Sendoel A, Sribour M, Fuchs E. An RNAi screen unravels the complexities of Rho GTPase networks in skin morphogenesis. elife. 2019;8: pubmed publisher
immunohistochemistry; mouse; 1:200; loading ...; fig 1b	Zhang X, Sullivan C, Kratz M, Kasten M, Maness P, Manis P. NCAM Regulates Inhibition and Excitability in Layer 2/3 Pyramidal Cells of Anterior Cingulate Cortex. Front Neural Circuits. 2017;11:19 pubmed publisher
immunohistochemistry; mouse; 1:1000; loading ...; fig 1f	Jørgensen L, Jepsen P, Boysen A, Dalgaard L, Hvid L, Ørtenblad N, et al. SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo. Am J Pathol. 2017;187:457-474 pubmed publisher
western blot; rat; 1:800; loading ...; fig 5b	Marco E, Ballesta J, Irala C, Hernández M, Serrano M, Mela V, et al. Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences. Pharmacol Biochem Behav. 2017;152:68-80 pubmed publisher
immunohistochemistry; chicken; fig 2	Stanic K, Saldivia N, Förstera B, Torrejon M, Montecinos H, Caprile T. Expression Patterns of Extracellular Matrix Proteins during Posterior Commissure Development. Front Neuroanat. 2016;10:89 pubmed
immunocytochemistry; human; 1:1000; loading ...; fig 1d western blot; human; 1:1000; loading ...; fig 1b	Jaako K, Waniek A, Parik K, Klimaviciusa L, Aonurm Helm A, Noortoots A, et al. Prolyl endopeptidase is involved in the degradation of neural cell adhesion molecules in vitro. J Cell Sci. 2016;129:3792-3802 pubmed
immunohistochemistry; mouse; 1:1000; fig s4	Genç B, Jara J, Schultz M, Manuel M, Stanford M, Gautam M, et al. Absence of UCHL 1 function leads to selective motor neuropathy. Ann Clin Transl Neurol. 2016;3:331-45 pubmed publisher
immunocytochemistry; human; fig 9 immunohistochemistry; human; 1:100; fig 9	Deborde S, Omelchenko T, Lyubchik A, Zhou Y, He S, McNamara W, et al. Schwann cells induce cancer cell dispersion and invasion. J Clin Invest. 2016;126:1538-54 pubmed publisher
	Voigt T, Tourville T, Falcone M, Slauterbeck J, Beynnon B, Toth M. Resistance training-induced gains in knee extensor strength are related to increased neural cell adhesion molecule expression in older adults with knee osteoarthritis. BMC Res Notes. 2019;12:595 pubmed publisher
	Kellish P, Shabashvili D, Rahman M, Nawab A, Guijarro M, Zhang M, et al. Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival. J Clin Invest. 2019;129:2279-2292 pubmed publisher
	Izumi Y, Wakita S, Kanbara C, Nakai T, Akaike A, Kume T. Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons. Sci Rep. 2017;7:42111 pubmed publisher
	Skog M, Nystedt J, Korhonen M, Anderson H, Lehti T, Pajunen M, et al. Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells. Stem Cell Res Ther. 2016;7:113 pubmed publisher
	Watzlawik J, Kahoud R, Ng S, Painter M, Papke L, Zoecklein L, et al. Polysialic acid as an antigen for monoclonal antibody HIgM12 to treat multiple sclerosis and other neurodegenerative disorders. J Neurochem. 2015;134:865-78 pubmed publisher

product information

Catalog Number :

AB5032

Subcategory :

Neuroscience

Product Name :

Anti-Neural Cell Adhesion Molecule Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P13592

Host Name :

Rabbit

Antigen :

Neural Cell Adhesion Molecule

Conjugate :

Affinity Purified

Product Description :

Anti-Neural Cell Adhesion Molecule Antibody

Cross Reactivity :

Chicken;Human;Mouse;Rat

Background :

The Immunoglobulin superfamily of cell adhesion molecules is related to the immunoglobulins proteins by structure. The family contains over a 100 members, which include ICAM (intercellular adhesion molecule), NCAM (neural cell adhesion molecule) and NgCAM (neural-glial cell adhesion molecule). Both NCAM and NgCAM are calcium independent adhesion molecules. NCAM, the first CAM to be characterized, is expressed on all neurons from very early in development. It binds homophilically to NCAM on adjacent cells and has a variety of functions during neural development. One of these important functions is to hold developing neurites together during neuron outgrowth and formation of neural connections. The adhesive properties of NCAM are modulated during development and plasticity by the presence of the regulated carbohydrate, polysialic acid (PSA). The post-translational addition of alpha-2,8-linked PSA (NCAM-PSA) appears to contribute to synaptic plasticity during learning and memory formation and to the mechanisms of nerve regeneration.

ALT Names :

CD56 antigen;antigen recognized by monoclonal antibody 5.1H11

Immunogen :

Highly purified chicken NCAM

Specificity :

Neural Cell Adhesion Molecule (NCAM). MW is 200-250 kDa; when treated with Neuraminidase, 140-180 kDa. A breakdown product of 160 kDa may also be visible.

Package Size :

50 µg

Uses :

ELISA;Immunofluorescence;Immunohistochemistry;Affects Function;Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.