Acetyl Lysine Antibody | EMD Millipore AB3879 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Acetyl Lysine Antibody

catalog :

AB3879

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 3

Reference
Sartor G, Malvezzi A, Kumar A, Andrade N, Wiedner H, Vilca S, et al. Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins. J Neurosci. 2019;39:612-626 pubmed publisher
Das D, Smith N, Wang X, Morgan I. The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2. J Virol. 2017;91: pubmed publisher
Leus N, van der Wouden P, van den Bosch T, Hooghiemstra W, Ourailidou M, Kistemaker L, et al. HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity. Biochem Pharmacol. 2016;108:58-74 pubmed publisher

product information

Catalog Number :

AB3879

Subcategory :

Cell Signaling

Product Name :

Anti-Acetyl Lysine Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Host Name :

Rabbit

Antigen :

Acetyl Lysine

Conjugate :

Affinity Purified

Product Description :

Anti-Acetyl Lysine Antibody

Cross Reactivity :

All

Background :

In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation.

Immunogen :

Acetylated KLH.

Specificity :

Recognizes proteins acetylated on lysine residues. This antibody recognizes multiple acetylated proteins including acetylated histones, acetylated BSA, and acetylated MBP, and exhibits no reaction with non-acetylated proteins.

Package Size :

100 µg

Uses :

ELISA;Immunofluorescence;Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.