Caspase 3 Antibody, active (cleaved) form | EMD Millipore AB3623 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Caspase 3 Antibody, active (cleaved) form

catalog :

AB3623

quantity :

50 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 16

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; loading ...; fig s2b	Latina V, Caioli S, Zona C, Ciotti M, Amadoro G, Calissano P. Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons. Front Cell Neurosci. 2017;11:68 pubmed publisher
western blot; mouse; 1:100; loading ...; fig 1a	Luke M, LeVatte T, Rutishauser U, Tremblay F, Clarke D. Polysialylated Neural Cell Adhesion Molecule Protects Against Light-Induced Retinal Degeneration. Invest Ophthalmol Vis Sci. 2016;57:5066-5075 pubmed publisher
immunohistochemistry - paraffin section; mouse; fig 4-s1	Dragich J, Kuwajima T, Hirose Ikeda M, Yoon M, Eenjes E, Bosco J, et al. Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain. elife. 2016;5: pubmed publisher
immunohistochemistry; rat; fig 1	Lim S, Jin L, Jin J, Yang C. Effect of Exendin-4 on Autophagy Clearance in Beta Cell of Rats with Tacrolimus-induced Diabetes Mellitus. Sci Rep. 2016;6:29921 pubmed publisher
western blot; mouse; fig 6	Tejada T, Tan L, Torres R, Calvert J, Lambert J, Zaidi M, et al. IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction. Proc Natl Acad Sci U S A. 2016;113:6949-54 pubmed publisher
immunohistochemistry; mouse; 1:500; fig 13	Li X, Gaillard F, Monckton E, Glubrecht D, Persad A, Moser M, et al. Loss of AP-2delta reduces retinal ganglion cell numbers and axonal projections to the superior colliculus. Mol Brain. 2016;9:62 pubmed publisher
immunohistochemistry - frozen section; rat; 1:100; fig 3	Keilhoff G, Lucas B, Uhde K, Fansa H. Selected gene profiles of stressed NSC-34 cells and rat spinal cord following peripheral nerve reconstruction and minocycline treatment. Exp Ther Med. 2016;11:1685-1699 pubmed
	Li H, Saucedo Cuevas L, Yuan L, Ross D, Johansen A, Sands D, et al. Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors. Neuron. 2019;101:1089-1098.e4 pubmed publisher
	Stafman L, Mruthyunjayappa S, Waters A, Garner E, Aye J, Stewart J, et al. Targeting PIM kinase as a therapeutic strategy in human hepatoblastoma. Oncotarget. 2018;9:22665-22679 pubmed publisher
	Kupferschmidt D, Juczewski K, Cui G, Johnson K, Lovinger D. Parallel, but Dissociable, Processing in Discrete Corticostriatal Inputs Encodes Skill Learning. Neuron. 2017;96:476-489.e5 pubmed publisher
	Lee C, Shin S, Lee J, Seo H, Lim K, Kim H, et al. MicroRNA-Mediated Down-Regulation of Apoptosis Signal-Regulating Kinase 1 (ASK1) Attenuates the Apoptosis of Human Mesenchymal Stem Cells (MSCs) Transplanted into Infarcted Heart. Int J Mol Sci. 2016;17: pubmed
	Hennessy E, Gormley S, López Rodríguez A, Murray C, Murray C, Cunningham C. Systemic TNF-? produces acute cognitive dysfunction and exaggerated sickness behavior when superimposed upon progressive neurodegeneration. Brain Behav Immun. 2017;59:233-244 pubmed publisher
	Deep S, Baitharu I, Sharma A, Gurjar A, Prasad D, Singh S. Neuroprotective Role of L-NG-Nitroarginine Methyl Ester (L-NAME) against Chronic Hypobaric Hypoxia with Crowding Stress (CHC) Induced Depression-Like Behaviour. PLoS ONE. 2016;11:e0153371 pubmed publisher
	Caglayan Sozmen S, Karaman M, Cilaker Mıcılı S, Işık S, Arıkan Ayyıldız Z, Bagriyanik A, et al. Resveratrol ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis-like lesions through effects on the epithelium. Peerj. 2016;4:e1889 pubmed publisher
	Franks S, Jones R, Briah R, Murray P, Moorehead R. BMS-754807 is cytotoxic to non-small cell lung cancer cells and enhances the effects of platinum chemotherapeutics in the human lung cancer cell line A549. BMC Res Notes. 2016;9:134 pubmed publisher
	Hinwood M, Tynan R, Charnley J, Beynon S, Day T, Walker F. Chronic stress induced remodeling of the prefrontal cortex: structural re-organization of microglia and the inhibitory effect of minocycline. Cereb Cortex. 2013;23:1784-97 pubmed publisher

product information

Catalog Number :

AB3623

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Caspase 3 Antibody, active (cleaved) form

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P42574

Host Name :

Rabbit

Antigen :

Caspase 3

Conjugate :

Affinity Purified

Product Description :

Anti-Caspase 3 Antibody, active (cleaved) form

Cross Reactivity :

Human;Mouse;Rat

Background :

Caspase-3 (CPP32, Apopain) is the most extensively studied apoptotic protein. Caspase-3 is synthesized as an inactive proenzyme (32 kDa) that is processed in cells undergoing apoptosis by self-proteolysis and/or cleavage by another upstream protease. The processed form of caspase-3 consists of large (17 kDa) and small (12 kDa) subunits which associate to form an active enzyme. The active caspase-3 proteolytically cleaves and activates other caspases, as well as relevant targets in the cells such as PARP and DFF.

ALT Names :

Apopain;Yama Protein;CASP3;SCA-1;procaspase3

Immunogen :

Cleavage specific synthetic peptide sequence (proprietary).

Specificity :

AB3623 detects only the cleaved p17 fragment and does not detect the precursor form in cells undergoing apoptosis.

Package Size :

50 μg

Uses :

Immunofluorescence;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.