Aquaporin 0 Antibody | EMD Millipore AB3071 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Aquaporin 0 Antibody

catalog :

AB3071

quantity :

50 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA

citations: 2

Reference
Mochizuki T, Kojima Y, Nishiwaki Y, Harakuni T, Masai I. Endocytic trafficking factor VPS45 is essential for spatial regulation of lens fiber differentiation in zebrafish. Development. 2018;145: pubmed publisher
Zhou Y, Shiels A. Epha2 and Efna5 participate in lens cell pattern-formation. Differentiation. 2018;102:1-9 pubmed publisher

product information

Catalog Number :

AB3071

Subcategory :

Neuroscience

Product Name :

Anti-Aquaporin 0 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P30301

Host Name :

Rabbit

Antigen :

Aquaporin 0

Conjugate :

Affinity Purified

Product Description :

Anti-Aquaporin 0 Antibody

Cross Reactivity :

Human

ALT Names :

AQP0; MIP; Major Intrinsic Protein

Immunogen :

A 17 AA synthetic peptide within the carboxy terminal domain of human Aquaporin-0 (Shiels et al. 1988; Kent et al. 1990; Pisano et al. 1991; Shiels et al. 1996) was selected for antibody production. This domain is predicted to be cytoplasmic.

Specificity :

Water is a critical component of all living cells. Interestingly, tissue membranes show a great degree of water permeability. Mammalian red cells, renal proximal tubules, and descending thin limb of Henle are extraordinarily permeable to water. Water crosses hydrophobic plasma membranes either by simple diffusion or through a facilitative transport mechanism mediated by special protein "aquaporin". Over the last decade, genes for several members of aquaporin family have been cloned, expressed, and their distribution studied in many tissues. Aquaporin-0 or MIP26 (major intrinsic protein 26 kDa), and Aquaporin-1 (purified from red cells) also called CHIP-28 (channel forming integral protein, 28 kDa; 268 AA; gene locus 7p14) has been the foundation of the growing family of aquaporins. The lens specific Aquaporin-0 represents up to 80% of total lens membrane protein. Defects in MIP26 are a cause of autosomal dominant cataract. The cataract Fraser mutation (CAT-FR or Shriveled) is a transposon-induced splicing error that substitutes a long terminal repeat sequence for the c-terminus of MIP. The lens opacity mutation (LOP) is an AA substitution that inhibits targeting of MIP to the cell membrane. Human Aquaporin-0 is a 263 amino acid transmembrane protein belonging to the MIP family. Aquaporin families of proteins are predicted to contain six transmembrane domains. The N and C-terminus are predicted to be cytoplasmic.

Package Size :

50 µg

Uses :

ELISA;Western Blotting

Storage :

Maintain frozen at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.