BNIP3 Antibody | EMD Millipore AB2999 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BNIP3 Antibody

catalog :

AB2999

quantity :

50 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, bovine

application :

western blot, immunocytochemistry

citations: 1

Reference
Brennan L, McGreal Estrada R, Logan C, Cvekl A, Menko A, Kantorow M. BNIP3L/NIX is required for elimination of mitochondria, endoplasmic reticulum and Golgi apparatus during eye lens organelle-free zone formation. Exp Eye Res. 2018;174:173-184 pubmed publisher

product information

Catalog Number :

AB2999

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-BNIP3 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q12983

Host Name :

Rabbit

Antigen :

BNIP3

Conjugate :

Affinity Purified

Product Description :

Anti-BNIP3 Antibody

Cross Reactivity :

Human;Mouse

Background :

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is a member of the NIP3 family, a singular group of death-inducing, mitochondrial proteins. BNIP3 is comprised of several domains of interest; a highly conserved domain (CD), a C-terminal transmembrane (TM) domain, and a BH3 domain. Strongly upregulated by hypoxia, BNIP3 induces a caspase-independent cell death characterized by mitochondrial damage. Overexpression has been observed in the brain after stroke and in the adult heart following myocardial infarction. Recent studies have shown BNIP3 to be involved in cell growth inhibition through suppression of the mTOR pathway and that, when localized to the nucleus, it has the paradoxical capability of repressing apoptosis in tumors by binding the AIF expression gene.

ALT Names :

BCL2/adenovirus E1B 19kDa interacting protein 3;BCL2/adenovirus E1B 19kD-interacting protein 3;BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Immunogen :

KLH-conjugated linear peptide corresponding to an internal region of human BNIP3.

Package Size :

50 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt