LYVE1 Antibody | EMD Millipore AB2988 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LYVE1 Antibody

catalog :

AB2988

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

immunohistochemistry

citations: 1

Reference
Ghaffari A, Hoskin V, Turashvili G, Varma S, Mewburn J, Mullins G, et al. Intravital imaging reveals systemic ezrin inhibition impedes cancer cell migration and lymph node metastasis in breast cancer. Breast Cancer Res. 2019;21:12 pubmed publisher

product information

Catalog Number :

AB2988

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-LYVE1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8BHC0

Host Name :

Rabbit

Antigen :

LYVE1

Conjugate :

Affinity Purified

Isotype :

IgG

Product Description :

Anti-LYVE1 Antibody

Cross Reactivity :

Human;Mouse

Background :

LYVE1 has been identified as a major receptor for HA (extracellular matrix glycosaminoglycan hyaluronan) on the lymph vessel wall. The deduced amino acid sequence of LYVE1 predicts a 322-residue type I integral membrane polypeptide 41% similar to the CD44 HA receptor with a 212-residue extracellular domain containing a single Link module the prototypic HA binding domain of the Link protein superfamily. Like CD44, the LYVE1 molecule binds both soluble and immobilized HA. However, unlike CD44, the LYVE1 molecule colocalizes with HA on the luminal face of the lymph vessel wall and is completely absent from blood vessels. Hence, LYVE1 is the first lymph-specific HA receptor to be characterized and is a uniquely powerful marker for lymph vessels themselves. LYVE1 may function in lymphatic hyaluronan transport. Additionally, LYVE1 has a role in tumor metastasis.

ALT Names :

Cell surface retention sequence-binding protein 1;Extracellular link domain-containing protein 1;Hyaluronic acid receptor;cell surface retention sequence binding protein-1;extracellular link domain containing 1;extracellular link domain-containing 1;lymphatic vessel endothelial hyaluronan receptor 1

Immunogen :

KLH-conjugated linear peptide corresponding to mouse LYVE1.

Specificity :

This antibody recognizes LYVE1.

Package Size :

100 μg

Uses :

Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt