Kindlin-3 Antibody | EMD Millipore AB2979 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Kindlin-3 Antibody

catalog :

AB2979

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dog, cow, chimpanzee

application :

western blot, immunocytochemistry

product information

Catalog Number :

AB2979

Subcategory :

Cell Structure

Product Name :

Anti-Kindlin-3 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q86UX7

Host Name :

Rabbit

Antigen :

Kindlin-3

Conjugate :

Affinity Purified

Product Description :

Anti-Kindlin-3 Antibody

Cross Reactivity :

Human;Mouse;Mouse;Rat;Ox;Canine;Chimpanzee

Background :

Kindlin-3 is an intracellular protein encoded by the FERMT3 gene and which binds directly to the β chain cytoplasmic tail of integrin in hematopoietic cells. This protein belongs to a family of adhesion plaque proteins, of which there are three members, which act to activate integrins. Kindlin-3 differs from Kindlins-1 and -2 in that its expression is restricted to hematopoietic systems and is especially high in spleen and megakaryocytes. It is a necessary component for integrin activation and for platelet aggregation. Mutations in FERMT3 and consequently to the encoding of Kindlin-3 protein are causal to LAD-I variant syndrome, an uncommon genetic disorder in which integrin adhesive functions on platelets and leukocytes are disrupted.

ALT Names :

MIG2-like protein;UNC-112 related protein 2;fermitin family homolog 3 (Drosophila);kindlin 3

Immunogen :

KLH-conjugated linear peptide corresponding to the FERM domain of human Kindlin-3.

Specificity :

The antibody recognizes the FERM domain of Kindlin-3.

Package Size :

100 μg

Uses :

Western Blotting;Immunocytochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt