MMP-12 Antibody, hinge region | EMD Millipore AB2964 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-12 Antibody, hinge region

catalog :

AB2964

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, chimpanzee

application :

western blot

product information

Catalog Number :

AB2964

Subcategory :

Cell Structure

Product Name :

Anti-MMP-12 Antibody, hinge region

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P39900

Host Name :

Rabbit

Antigen :

MMP-12

Conjugate :

Affinity Purified

Product Description :

Anti-MMP-12 Antibody, hinge region

Cross Reactivity :

Human

Background :

Matrix metallopeptidase 12 (MMP-12) is able to degrade elastin, entactin, laminin-1, fibronectin, type IV collagen as well as insulin B-chain and casein. MMP-12 is structurally similar to the classical MMPs (MMP-1, MMP-3); it contains a propeptide with autoinhibitory cysteine switch site, a well conserved zinc site, hinge region and hemopexin domain. MMP-12 lacks a transmembrane domain and furin cleavage site. The zymogen for MMP-12 is about 54 kDa, and is quickly activated to the 45 kDa form, and this breaks down to cascade of active forms, ending with the common 22 kDa form.Stimulated macrophages produce MMP-12; it has also been found in osteosarcoma cells, synovial fibroblasts and lung fibroblasts. MMP-12 levels in quiescent cells and tissues are minimal (with the exception of macrophages), and mitogen stimulation or protein concentration is often needed to visualize the bands. In addition, cell types differ greatly in the quantity of MMP-12 produced.

ALT Names :

Macrophage elastase;Matrix metalloproteinase-12;macrophage metalloelastase;matrix metallopeptidase 12

Immunogen :

KLH-conjugated linear peptide corresponding to human MMP-12.

Specificity :

Recognizes the hinge region of MMP-12.

Package Size :

100 μg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt