BMAL1 Antibody | EMD Millipore AB2298 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BMAL1 Antibody

catalog :

AB2298

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, domestic horse

application :

western blot

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:3000; loading ...; fig 2c	Li P, Fu X, Smith N, Ziobro J, Curiel J, Tenga M, et al. Loss of CLOCK Results in Dysfunction of Brain Circuits Underlying Focal Epilepsy. Neuron. 2017;96:387-401.e6 pubmed publisher
	Díaz N, Morera L, Verra D, Contin M, Guido M. Early appearance of nonvisual and circadian markers in the developing inner retinal cells of chicken. Biomed Res Int. 2014;2014:646847 pubmed publisher

product information

Catalog Number :

AB2298

Subcategory :

Neuroscience

Product Name :

Anti-BMAL1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O00327

Host Name :

Rabbit

Antigen :

BMAL1

Conjugate :

Purified

Product Description :

Anti-BMAL1 Antibody

Cross Reactivity :

Human;Mouse;Rat;Opossum;Bovine;Primate;Monkey

Background :

Brain and muscle Arnt-like protein-1 (BMAL1; also known as MOP3 or Arnt3) is a transcription factor known to regulate circadian rhythm. BMAL1 is the only component of the mammalian circadian clock whose sole deletion in a mouse model generates arrhythmicity. In addition to defects in the clock, these BMAL1 null-mice also have reproductive problems are small in stature, age quickly and have progressive arthropathy that results in having less overall locomotor activity than wild type mice. Recent phenotyping data suggests that BMAL1 and its partner Clock also play a role in regulation of glucose homeostasis and metabolism. Finally, BMAL1, NPAS2, and PER2 have been associated with seasonal affective disorder in humans. BMAL1 transcription is circadian and reciprocally regulated by NR1D1 (Rev-erb-alpha) and RORA, which establishes a second interlocking loop in the mammalian circadian clock.

ALT Names :

Aryl hydrocarbon receptor nuclear translocator-like protein 1;Brain and muscle ARNT-like 1;Member of PAS protein 3;Basic-helix-loop-helix-PAS protein MOP3;bHLH-PAS protein JAP3

Immunogen :

KLH conjugated synthetic linear peptide corresponding to the internal domain of BMAL1.

Specificity :

Cat. # AB2298 recognizes the internal domain of BMAL1.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.