Amyloid Fibrils OC Antibody | EMD Millipore AB2286 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Amyloid Fibrils OC Antibody

catalog :

AB2286

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, dot blot

citations: 10

Published Application/Species/Sample/Dilution	Reference
dot blot; mouse; loading ...; fig 5c	Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed
immunohistochemistry; mouse; fig 1	Yuan P, Grutzendler J. Attenuation of Î²-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. J Neurosci. 2016;36:632-41 pubmed publisher
	Farmer K, Ghag G, Puangmalai N, Montalbano M, Bhatt N, Kayed R. P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer's disease. Acta Neuropathol Commun. 2020;8:132 pubmed publisher
	Castellanos M, Torres Pardo A, Rodriguez Perez R, Gasset M. Amyloid Assembly Endows Gad m 1 with Biomineralization Properties. Biomolecules. 2018;8: pubmed publisher
	Jayaraman S, Gantz D, Haupt C, Gursky O. Serum amyloid A forms stable oligomers that disrupt vesicles at lysosomal pH and contribute to the pathogenesis of reactive amyloidosis. Proc Natl Acad Sci U S A. 2017;114:E6507-E6515 pubmed publisher
	Keskin A, Keku M, Adelsberger H, Neumann U, Shimshek D, Song B, et al. BACE inhibition-dependent repair of Alzheimer's pathophysiology. Proc Natl Acad Sci U S A. 2017;114:8631-8636 pubmed publisher
	Ye L, Rasmussen J, Kaeser S, Marzesco A, Obermüller U, Mahler J, et al. Aβ seeding potency peaks in the early stages of cerebral β-amyloidosis. EMBO Rep. 2017;18:1536-1544 pubmed publisher
	Bolognesi B, Lorenzo Gotor N, Dhar R, Cirillo D, Baldrighi M, Tartaglia G, et al. A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression. Cell Rep. 2016;16:222-231 pubmed publisher
	Hayes M, Weeks D. Amyloids assemble as part of recognizable structures during oogenesis in Xenopus. Biol Open. 2016;5:801-6 pubmed publisher
	Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar AÎ²42 hotspots around plaques. Nat Commun. 2015;6:6176 pubmed publisher

product information

Catalog Number :

AB2286

Subcategory :

Neuroscience

Product Name :

Anti-Amyloid Fibrils OC Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05067

Host Name :

Rabbit

Antigen :

Amyloid Fibrils OC

Conjugate :

Serum

Isotype :

IgG

Product Description :

Anti-Amyloid Fibrils OC Antibody

Cross Reactivity :

Human

Background :

Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. In disease state oligomerization, extensive amyloid oligomerization creates plaques in neural tissue that correlates with Alzheimer’s symptomology.

ALT Names :

Amyloid Fibrils, Amyloid Fibrils OC

Immunogen :

Fibrils prepared from human Aß42 peptide.

Specificity :

This antibody recognizes generic epitopes common to many amyloid fibrils and fibrillar oligomers, but not prefibrillar oligomers or natively folded proteins. It may also show weak reactivity against Aβ monomers while AB2287 does not.

Package Size :

100 µL

Uses :

Immunoprecipitation;Immunocytochemistry;Immunohistochemistry;ELISA;Western Blotting;Dot Blot

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.