Na+K+Cl- Cotransporter 2 Antibody | EMD Millipore AB2281 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Na+K+Cl- Cotransporter 2 Antibody

catalog :

AB2281

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

AB2281

Subcategory :

Neuroscience

Product Name :

Anti-Na+K+Cl- Cotransporter 2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13621

Host Name :

Rabbit

Antigen :

Na+K+Cl- Cotransporter 2

Conjugate :

Affinity Purified

Product Description :

Anti-Na+K+Cl- Cotransporter 2 Antibody

Cross Reactivity :

Rat;Mouse;Human

Background :

The sodium-potassium-chloride cotransporter isoform 2 is kidney-specific and is found on the apical membrane of the thick ascending limb of Henle's loop and the macula densa. It accounts for most of the NaCl resorption with the stoichiometry of 1Na:1K:2Cl and is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. SLC12A1 is kidney specific and is essential in the regulation of ionic balance and cell volume. It is a component of an electrically silent transporter system, mediating sodium and chloride reabsorption. Defects in SLC12A1 are the cause of Bartter syndrome type 1, an autosomal recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria.

ALT Names :

Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2;Kidney-specific Na-K-Cl symporter;NKCC2A variant A;Na-K-2Cl cotransporter ;sodium potassium chloride cotransporter 2;solute carrier family 12 (sodium/potassium/chloride transporters), member 1

Immunogen :

KLH conjugate followed by NA+K+CL- Cotransporter 2 corresponding to the cytoplasmic domain.

Specificity :

This antibody recognizes the cytoplasmic domain of NA+K+CL- Cotransporter 2.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.