ZO-2 Antibody | EMD Millipore AB2273 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ZO-2 Antibody

catalog :

AB2273

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, chimpanzee

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Catalog Number :

AB2273

Subcategory :

Cell Structure

Product Name :

Anti-ZO-2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9UDY2

Host Name :

Rabbit

Antigen :

ZO-2

Conjugate :

Affinity Purified

Product Description :

Anti-ZO-2 Antibody

Cross Reactivity :

Human

Background :

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane associated guanylate kinase (MAGUK) family and include occludin and zona occludin family members ZO-1, ZO-2 and ZO-3. These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.

ALT Names :

tight junction protein 2 (zona occludens 2);tight junction protein ZO 2;tight junction protein ZO-2;Zona occludens protein 2;Friedreich ataxia region gene X104 (tight junction protein ZO-2);Zonula occludens protein 2;Tight junction protein 2

Immunogen :

Linear peptide corresponding to the PDZ3 domain of human ZO-2.

Specificity :

This antibody recognizes ZO-2 at the PDZ3 domain.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry (Paraffin)

Storage :

Stable for 1 year at 2-8°C from date of receipt