GABA B Receptor R2 Antibody | EMD Millipore AB2255 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GABA B Receptor R2 Antibody

catalog :

AB2255

quantity :

100 µL

clonality :

polyclonal

host :

guinea-pigs

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine, chimpanzee

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; 1:500; fig 1b	Zemoura K, Trümpler C, Benke D. Lys-63-linked Ubiquitination of ?-Aminobutyric Acid (GABA), Type B1, at Multiple Sites by the E3 Ligase Mind Bomb-2 Targets GABAB Receptors to Lysosomal Degradation. J Biol Chem. 2016;291:21682-21693 pubmed
	Zemoura K, Balakrishnan K, Grampp T, Benke D. Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABAB1 Triggers Lysosomal Degradation of GABAB Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination. Mol Neurobiol. 2019;56:1293-1309 pubmed publisher

product information

Catalog Number :

AB2255

Subcategory :

Neuroscience

Product Name :

Anti-GABA B Receptor R2 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O88871

Host Name :

Guinea Pig

Antigen :

GABA B Receptor R2

Conjugate :

Serum

Product Description :

Anti-GABA B Receptor R2 Antibody

Cross Reactivity :

Rat;Human;Bovine;Horse;Rhesus Macaque;Chimpanzee;Mouse;Canine

Background :

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic [GABA(A/C)] receptors, to produce fast synaptic inhibition, and metabotropic [GABA(B)] receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates 4 transcript variants.

ALT Names :

G protein-coupled receptor 51;G-protein coupled receptor 51;GABA-B receptor 2;gamma-aminobutyric acid (GABA) B receptor, 2;gamma-aminobutyric acid B receptor, 2;GABA-B-R2;GABA(B)R2

Immunogen :

Bovine thyroglobulin-conjugated linear peptide at the C-terminus of rat GABA-B-R2.

Specificity :

This antibody recognizes the C-terminus of rat GABA-B-R2.

Package Size :

100 µL

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.