Dopamine Transporter; 100 µg Antibody | EMD Millipore AB2231 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dopamine Transporter; 100 µg Antibody

catalog :

AB2231

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:20,000; loading ...; fig 4c	Curry D, Young M, Tran A, Daoud G, Howell L. Separating the agony from ecstasy: R(-)-3,4-methylenedioxymethamphetamine has prosocial and therapeutic-like effects without signs of neurotoxicity in mice. Neuropharmacology. 2018;128:196-206 pubmed publisher
western blot; rat; 1:1000	Hryhorczuk C, Florea M, Rodaros D, Poirier I, Daneault C, Des Rosiers C, et al. Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids. Neuropsychopharmacology. 2016;41:811-21 pubmed publisher
	Calipari E, Juarez B, Morel C, Walker D, Cahill M, Ribeiro E, et al. Dopaminergic dynamics underlying sex-specific cocaine reward. Nat Commun. 2017;8:13877 pubmed publisher

product information

Catalog Number :

AB2231

Subcategory :

Neuroscience

Product Name :

Anti-Dopamine Transporter; 100 µg Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q01959

Host Name :

Rabbit

Antigen :

Dopamine Transporter

Conjugate :

Purified

Product Description :

Anti-Dopamine Transporter; 100 µg Antibody

Cross Reactivity :

Mouse;Rat

Background :

Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT), a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. DAT is also the target of several “DAT-blockers” including amphetamines and cocaine. These chemicals inhibit the action of DAT and, to a lesser extent, the other monoamine transporters, but their effects are mediated by separate mechanisms.

ALT Names :

DA transporter;dopamine transporter ;solute carrier family 6 (neurotransmitter transporter, dopamine),member 3 ;variable number tandem repeat (VNTR)

Immunogen :

Synthetic Linear Peptide

Specificity :

Cat. AB2231 recognizes the N-terminus of the reduced and non reduced forms of DAT.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt. Handling Recommendations: Prior to removing the cap, gently centrifuge the vial and gently mix the solution.