phospho STEP61/46 Antibody, (Ser221/Ser49) | EMD Millipore AB2208 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho STEP61/46 Antibody, (Ser221/Ser49)

catalog :

AB2208

quantity :

100 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry

product information

Catalog Number :

AB2208

Subcategory :

Neuroscience

Product Name :

Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P54830

Host Name :

Rabbit

Antigen :

phospho STEP61/46

Conjugate :

Affinity Purified

Product Description :

Anti-phospho STEP61/46 Antibody, (Ser221/Ser49)

Cross Reactivity :

Mouse;Human;Rhesus Macaque;Bovine;Rat

Background :

Striatum-enriched protein-tyrosine phosphatase (STEP) isoforms 61 and 46 are two of the many splice variants for STEP, a protein belonging to the protein-tyrosine phosphatase family and containing a single tyrosine-protein phosphatase domain. STEP61 is membrane-associated, where as STEP46 is cytosolic. STEP61 also differs in that it contains a sequence of 172 amino acids with structural motifs not found in STEP46. Both isoforms are phosphorylated on serine residues, although STEP61 is mainly phosphorylated at Ser160 and Ser221, while STEP46 is phosphorylated at Ser49. STEP is thought to have a critical role in regulating dopamine efficacy on striatial medium spiny neurons, neurotransmission through the NMDAR pathway, and AMPA receptor endocytosis.

ALT Names :

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched);protein-tyrosine phosphatase striatum-enriched;tyrosine-protein phosphatase non-receptor type 5;Striatum-enriched protein-tyrosine phosphatase;Neural-specific protein-tyrosine phosphatase

Immunogen :

KLH-conjugated linear peptide corresponding to mouse STEP61/46 phosphorylated at Ser221/Ser49.

Specificity :

This antibody recognizes STEP61/46 when phosphorylated at Ser221/Ser49.

Package Size :

100 μg

Uses :

Western Blotting;Immunohistochemistry

Storage :

Stable for 1 year at 2-8°C from date of receipt