Neurofilament M (145 kDa) Antibody, CT | EMD Millipore AB1987 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Neurofilament M (145 kDa) Antibody, CT

catalog :

AB1987

quantity :

50 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; rat; loading ...; fig 7	Vazquez Cintron E, Beske P, Tenezaca L, Tran B, Oyler J, Glotfelty E, et al. Engineering Botulinum Neurotoxin C1 as a Molecular Vehicle for Intra-Neuronal Drug Delivery. Sci Rep. 2017;7:42923 pubmed publisher
immunohistochemistry; mouse; 1:200; fig 2c western blot; mouse; loading ...; fig 5f	Brügger V, Duman M, Bochud M, Münger E, Heller M, Ruff S, et al. Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration. Nat Commun. 2017;8:14272 pubmed publisher
immunocytochemistry; mouse; loading ...; fig 2a western blot; mouse; loading ...; fig 2d	Wakatsuki S, Tokunaga S, Shibata M, Araki T. GSK3B-mediated phosphorylation of MCL1 regulates axonal autophagy to promote Wallerian degeneration. J Cell Biol. 2017;216:477-493 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:1000; fig s3	Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed publisher
immunohistochemistry; human; 1:200; loading ...; fig s1d	Uchida H, Morita T, Niizuma K, Kushida Y, Kuroda Y, Wakao S, et al. Transplantation of Unique Subpopulation of Fibroblasts, Muse Cells, Ameliorates Experimental Stroke Possibly via Robust Neuronal Differentiation. Stem Cells. 2016;34:160-73 pubmed publisher
	Zwilling M, Theiss C, Matschke V. Caffeine and NAD+ Improve Motor Neural Integrity of Dissociated Wobbler Cells In Vitro. Antioxidants (Basel). 2020;9: pubmed publisher
	Vaquié A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, et al. Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration. Cell Rep. 2019;27:3152-3166.e7 pubmed publisher
	Varum S, Baggiolini A, Zurkirchen L, Atak Z, Cantù C, Marzorati E, et al. Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation. Cell Stem Cell. 2019;24:637-653.e9 pubmed publisher
	Diacou R, Zhao Y, Zheng D, Cvekl A, Liu W. Six3 and Six6 Are Jointly Required for the Maintenance of Multipotent Retinal Progenitors through Both Positive and Negative Regulation. Cell Rep. 2018;25:2510-2523.e4 pubmed publisher
	Adiutori R, Aarum J, Zubiri I, Bremang M, Jung S, Sheer D, et al. The proteome of neurofilament-containing protein aggregates in blood. Biochem Biophys Rep. 2018;14:168-177 pubmed publisher
	Yonekubo S, Tatemichi S, Maruyama K, Kobayashi M. Alpha1A-adrenoceptor antagonist improves underactive bladder associated with diabetic cystopathy via bladder blood flow in rats. BMC Urol. 2017;17:64 pubmed publisher
	Erskine L, François U, Denti L, Joyce A, Tillo M, Bruce F, et al. VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels. Development. 2017;144:2504-2516 pubmed publisher
	Zhu Y, Vidaurre O, Adula K, Kezunovic N, Wentling M, Huntley G, et al. Subcellular Distribution of HDAC1 in Neurotoxic Conditions Is Dependent on Serine Phosphorylation. J Neurosci. 2017;37:7547-7559 pubmed publisher
	Ellett L, Hung L, Munckton R, Sherratt N, Culvenor J, Grubman A, et al. Restoration of intestinal function in an MPTP model of Parkinson's Disease. Sci Rep. 2016;6:30269 pubmed publisher

product information

Catalog Number :

AB1987

Subcategory :

Neuroscience

Product Name :

Anti-Neurofilament M (145 kDa) Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P07197

Host Name :

Rabbit

Antigen :

Neurofilament M (145 kDa)

Conjugate :

Serum

Product Description :

Anti-Neurofilament M (145 kDa) Antibody, CT

Cross Reactivity :

Bovine;Chicken;Human;Mouse;Pig;Rat;Quail;Rabbit;Reptile

Background :

Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments.

Immunogen :

Recombinant fusion protein containing the C-terminal 168 amino acids of rat NF-M

Specificity :

Strong and specific staining for NF-M (145 kDa)

Package Size :

50 µL

Uses :

Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20ºC in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.