VE-Cadherin Antibody, phospho-specific [Tyr658] | EMD Millipore AB1955 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

VE-Cadherin Antibody, phospho-specific [Tyr658]

catalog :

AB1955

quantity :

100 µL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog, chicken, cow, chimpanzee

application :

western blot

citations: 1

Reference
Chung A, Kowanetz M, Wu X, Zhuang G, Ngu H, Finkle D, et al. Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors. J Pathol. 2012;227:404-16 pubmed publisher

product information

Catalog Number :

AB1955

Subcategory :

Cell Structure

Product Name :

Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P33151

Host Name :

Rabbit

Antigen :

VE-Cadherin

Conjugate :

Affinity Purified

Product Description :

Anti-VE-Cadherin Antibody, phospho-specific [Tyr658]

Cross Reactivity :

Human

Background :

VE-cadherin is an endothelial specific adhesion molecule that is essential for the maintenance of endothelial barrier function and angiogenesis. It is linked to the actin cytoskeleton through a number of adaptor proteins including alpha, beta, and gamma catenin. Cytoskeletal dynamics and phosphorylation regulate VE-cadherin mediated cellcell adhesion. The interaction between cytosolic c-terminal Src kinase, SH2 domain and phosphorylated tyrosine 658 site of VE-Cadherin regulates density dependent cell proliferation. Phosphorylation of tyrosine 658 has been shown to lead to uncoupling of p120-catenin from the cytoplasmic tail of VE-cadherin. This phosphorylation event is sufficient to maintain cells in a mesenchymal state during the cell invasion phase of angiogenesis.

Immunogen :

Phosphorylated VE-cadherin (Tyr658) synthetic peptide corresponding to human amino acid residues around tyrosine 658. The sequence is conserved in mouse, rat, porcine, bovine, canine, chicken and chimpanzee.

Specificity :

The antibody detects a 120 kDa protein of VE-cadherin.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Maintain at -20°C for up to one year or 2°-8°C for short term storage from date of receipt. Avoid repeated freeze/thaw cycles.