Integrin beta1 Antibody, Cytosolic | EMD Millipore AB1952 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin beta1 Antibody, Cytosolic

catalog :

AB1952

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat, dogs, zebrafish

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section

citations: 8

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; zebrafish ; fig 6a	Xia P, Gütl D, Zheden V, Heisenberg C. Lateral Inhibition in Cell Specification Mediated by Mechanical Signals Modulating TAZ Activity. Cell. 2019;176:1379-1392.e14 pubmed publisher
western blot; dogs; loading ...; fig 2d	Zhang K, MyllymÃ¤ki S, Gao P, Devarajan R, KytÃ¶lÃ¤ V, Nykter M, et al. Oncogenic K-Ras upregulates ITGA6 expression via FOSL1 to induce anoikis resistance and synergizes with Î±V-Class integrins to promote EMT. Oncogene. 2017;36:5681-5694 pubmed publisher
western blot; rat; 1:500; fig 1	Heintz T, Eva R, Fawcett J. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. PLoS ONE. 2016;11:e0158558 pubmed publisher
immunohistochemistry - frozen section; rat; 1:100; fig 9	Gao Y, Lui W, Lee W, Cheng C. Polarity protein Crumbs homolog-3 (CRB3) regulates ectoplasmic specialization dynamics through its action on F-actin organization in Sertoli cells. Sci Rep. 2016;6:28589 pubmed publisher
	Follain G, Osmani N, Azevedo A, Allio G, Mercier L, Karreman M, et al. Hemodynamic Forces Tune the Arrest, Adhesion, and Extravasation of Circulating Tumor Cells. Dev Cell. 2018;45:33-52.e12 pubmed publisher
	Ricciardiello F, Votta G, Palorini R, Raccagni I, Brunelli L, Paiotta A, et al. Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis. Cell Death Dis. 2018;9:377 pubmed publisher
	Majkowska I, Shitomi Y, Ito N, Gray N, Itoh Y. Discoidin domain receptor 2 mediates collagen-induced activation of membrane-type 1 matrix metalloproteinase in human fibroblasts. J Biol Chem. 2017;292:6633-6643 pubmed publisher
	Barrow McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche B, et al. Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun. 2016;7:11942 pubmed publisher

product information

Catalog Number :

AB1952

Subcategory :

Cell Structure

Product Name :

Anti-Integrin beta1 Antibody, Cytosolic

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05556

Host Name :

Rabbit

Antigen :

Integrin beta1

Conjugate :

Serum

Product Description :

Anti-Integrin beta1 Antibody, Cytosolic

Cross Reactivity :

Human;Mouse;Rat;Pig

Background :

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptors that bind to specific extracellular matrix proteins. Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to activation of signal transduction pathways and regulation of gene expression.

ALT Names :

CD29

Immunogen :

Synthetic peptide corresponding to the c-terminal cytoplasmic domain of human β-1 integrin.

Specificity :

Reactive with human, mouse and rat integrin β-1, as confirmed by western blot. Not reactive with other integrins.

Package Size :

100 µL

Uses :

Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.