Integrin β5 Antibody, CT/cytosolic | EMD Millipore AB1926 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin β5 Antibody, CT/cytosolic

catalog :

AB1926

quantity :

100 μL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, radioimmunoassay, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:80; loading ...; fig 1h	Abe A, Hashimoto K, Akiyama A, Iida M, Ikeda N, Hamano A, et al. αvβ5 integrin mediates the effect of vitronectin on the initial stage of differentiation in mouse cerebellar granule cell precursors. Brain Res. 2018;1691:94-104 pubmed publisher
	He Z, Forest F, Gain P, Rageade D, Bernard A, Acquart S, et al. 3D map of the human corneal endothelial cell. Sci Rep. 2016;6:29047 pubmed publisher

product information

Catalog Number :

AB1926

Subcategory :

Cell Structure

Product Name :

Anti-Integrin β5 Antibody, CT/cytosolic

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P18084

Host Name :

Rabbit

Antigen :

Integrin β5

Conjugate :

Serum

Product Description :

Anti-Integrin β5 Antibody, CT/cytosolic

Cross Reactivity :

Human;Hamster;Mouse;Rat

Background :

The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The beta5 subunit associates with alphaV forming a receptor for vitronectin. This complex is expressed in a wide range of cell types including fibroblast and keratinocytes. It is also expressed at high levels in several tumors including lung, pancreatic and mammary carcinomas. It is not expressed in lymphblastoid cells.

Immunogen :

Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human integrin beta 5 subunit (KTFNKFNKSYNGTVD). Note : a lysine (K) residue was added to the N-terminal of the peptide to facilitate coupling to the carrier protein.

Specificity :

Recognizes Integrin beta5. Specificity determined by immunoprecipitation from detergent extract of 35S methionine labeled cells. No cross-reactivity to beta1 or beta3.

Package Size :

100 μL

Uses :

ELISA;Immunofluorescence;Immunohistochemistry (Paraffin);Immunoprecipitation;Radioimmunoassay;Western Blotting

Storage :

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.