Integrin α3 Antibody | EMD Millipore AB1920 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Integrin α3 Antibody

catalog :

AB1920

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, radioimmunoassay

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:250; loading ...; fig 6b	Hunter D, Manglapus M, Bachay G, Claudepierre T, Dolan M, Gesuelli K, et al. CNS synapses are stabilized trans-synaptically by laminins and laminin-interacting proteins. J Comp Neurol. 2017;: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 4b	Reynolds L, D Amico G, Lechertier T, Papachristodoulou A, Muñoz Félix J, De Arcangelis A, et al. Dual role of pericyte ?6?1-integrin in tumour blood vessels. J Cell Sci. 2017;130:1583-1595 pubmed publisher
immunocytochemistry; rat; 1:500; fig 1	Heintz T, Eva R, Fawcett J. Regional Regulation of Purkinje Cell Dendritic Spines by Integrins and Eph/Ephrins. PLoS ONE. 2016;11:e0158558 pubmed publisher
	Martin K, Pritchett J, Llewellyn J, Mullan A, Athwal V, Dobie R, et al. PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis. Nat Commun. 2016;7:12502 pubmed publisher
	Yang D, Bierman J, Tarumi Y, Zhong Y, Rangwala R, Proctor T, et al. Coordinate control of axon defasciculation and myelination by laminin-2 and -8. J Cell Biol. 2005;168:655-66 pubmed

product information

Catalog Number :

AB1920

Subcategory :

Cell Structure

Product Name :

Anti-Integrin α3 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P26006

Host Name :

Rabbit

Antigen :

Integrin α3

Conjugate :

Serum

Product Description :

Anti-Integrin α3 Antibody

Cross Reactivity :

Bovine;Canine;Chicken;Goat;Hamster;Horse;Human;Mouse;Pig;Rat;Sheep

Background :

Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 19 alpha and 8 beta subunits that form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. Both of the subunits contribute to the binding of the ligand. The alpha-3 subunit (CD49c) is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. The alpha-3 subunit exists in two different splice variants, denoted as "A" and "B". The only difference that results from this differential splicing is a total change in the cytoplasmic domain, while the extracellular domain stays the same. Knock-out mice lacking this subunit show prenatal lethality and abnormalities in the kidneys.

ALT Names :

CD49c

Immunogen :

A synthetic peptide (CRIQPSETERLTDDY) derived from the COOH terminal sequence located in the cytoplasmic domain of the human alpha3 integrin subunit.

Specificity :

Integrin alpha3. Specificity determined by immunoprecipitation from a detergent extract of 35S-methionine labeled neuroblastoma cells. No cross-reactivity to alpha1, alpha2, alpha4, alpha5, alpha6, or alphaV integrins.

Package Size :

100 µL

Uses :

ELISA;Immunofluorescence;Immunohistochemistry;Immunoprecipitation;Radioimmunoassay;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.