MMP-2 Antibody, whole molecule | EMD Millipore AB19167 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

MMP-2 Antibody, whole molecule

catalog :

AB19167

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Luo F, Tran A, Xin L, Sanapala C, Lang B, Silver J, et al. Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun. 2018;9:4126 pubmed publisher
Hsu J, McKeon R, Goussev S, Werb Z, Lee J, Trivedi A, et al. Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injury. J Neurosci. 2006;26:9841-50 pubmed

product information

Catalog Number :

AB19167

Subcategory :

Cell Structure

Product Name :

Anti-MMP-2 Antibody, whole molecule

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P08253

Host Name :

Rabbit

Antigen :

MMP-2

Conjugate :

Purified

Product Description :

Anti-MMP-2 Antibody, whole molecule

Cross Reactivity :

Bovine;Human;Mouse;Rat

Background :

MMPs have a common mode of activation, a conserved amino acid sequence in the putative metal-binding active site region and are inhibited by specific tissue inhibitors of metalloproteinases (TIMPs). These MMPs and TIMPs could be expressed by either the cancer of the stromal cells. There is a co-operation between tumor and stromal cells, in particular for the production of 72-kD type IV collagenase, involved in the disruption of basement membranes. A lack of TIMP-1 expression from invasive cancer cells could also contribute to matrix destruction.

ALT Names :

72 kDa gelatinase;72kD type IV collagenase;Gelatinase A;Matrix metalloproteinase-2;collagenase type IV-A;matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase);matrix metalloproteinase 2;matrix metalloproteinase 2 (gelatinase A, 72kD gelatinase, 72kD type IV collagenase);matrix metalloproteinase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase);matrix metalloproteinase-II;neutrophil gelatinase

Immunogen :

A synthetic peptide from the second half of human MMP-2.

Specificity :

AB19167 recognizes protein at 72 kDa, identified as matrix metalloproteinase 2. MMP-2 is also known as 72 kDa collagenase IV or gelatinase A. It is synthesized as a 631 amino acid proenzyme that is activated by cleavage of the first 80 amino acids. AB19167 shows no cross-reaction with (pro) and active forms of other MMPs. Cytoplasmic localization.

Package Size :

100 µg

Uses :

Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at 2-8ºC from date of receipt.