ADAM 15 Antibody, CT | EMD Millipore AB19036 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ADAM 15 Antibody, CT

catalog :

AB19036

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Reference
Lorenzatti Hiles G, Bucheit A, Rubin J, Hayward A, Cates A, Day K, et al. ADAM15 Is Functionally Associated with the Metastatic Progression of Human Bladder Cancer. PLoS ONE. 2016;11:e0150138 pubmed publisher

product information

Catalog Number :

AB19036

Subcategory :

Cell Structure

Product Name :

Anti-ADAM 15 Antibody, CT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13444

Host Name :

Rabbit

Antigen :

ADAM 15

Conjugate :

Affinity Purified

Product Description :

Anti-ADAM 15 Antibody, CT

Cross Reactivity :

Human

ALT Names :

Metargidin; MDC15

Immunogen :

A synthetic peptide derived from the C-terminal end of the cytoplasmic domain of human ADAM15

Specificity :

The ADAM (A Disintegrin and Metalloprotease) family of cell surface proteases mediate a number of cellular processes, including differentiation, cell fusion, cell-cell interactions, and shedding of plasma membrane-bound growth factor precursors1. Each ADAM contains a prodomain, a catalytic metalloprotease domain, a disintegrin domain, a transmembrane domain, and a cytoplasmic domain1. The cytoplasmic domain of ADAM15 is phosphorylated and interacts with Src family tyrosine kinases2. ADAM15 contains an RGD sequence within its disintegrin domain, and thus has been given the trivial name metargidin. In HUVEC, ADAM15 localizes to adherens junctions3. Although the mature ADAM15 has a molecular weight of 100 kD, ADAM family members can undergo proteolytic processing autocatalytically or by furin proteases to yield smaller molecular weight forms. This antibody recognizes the 100 kD full-length form in HUVEC lysates, but other forms are possible in different cell and tissue types.

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain frozen at -20°C for up to 12 months.