C-X-C Chemokine Receptor 4 Antibody, extracellular loop | EMD Millipore AB1847 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

C-X-C Chemokine Receptor 4 Antibody, extracellular loop

catalog :

AB1847

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

product information

Catalog Number :

AB1847

Subcategory :

Inflammation & Immunology

Product Name :

Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P61073

Host Name :

Rabbit

Antigen :

C-X-C Chemokine Receptor 4

Conjugate :

Purified

Product Description :

Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop

Cross Reactivity :

Human;Mouse

ALT Names :

CD184; CXCR4

Immunogen :

Extracellular loop peptide of human CXCR4 (Berson et al. 1996; Leotscher et al. 1994).

Specificity :

Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors (Nimitrov 1997). Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principle coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells (Feng et al. 1996; Berson et al. 1996). CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2 (Doranz et al. 1996; Endres et al. 1996). The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1 (Bleul et al. 1996; Oberlin et al. 1996). CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells (Lapham et al. 1996). CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types (Feng et al. 1996). Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells (Feng et al. 1996; Endres et al. 1996; Brelot et al. 1997). The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites (Brelot et al. 1997; Lu et al. 1997).

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Can be refrigerated at 2-8°C in undiluted aliquots for up to 12 months from date of receipt.