Glutamate Transporter Antibody, Glial | EMD Millipore AB1783 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Glutamate Transporter Antibody, Glial

catalog :

AB1783

quantity :

50 µL

clonality :

polyclonal

host :

guinea-pigs

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry knockout validation

citations: 13

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry knockout validation; mouse; 1:2000; loading ...; fig 1e	Jia Y, Wininger K, Ho A, Peyton L, Baker M, Choi D. Astrocytic Glutamate Transporter 1 (GLT1) Deficiency Reduces Anxiety- and Depression-Like Behaviors in Mice. Front Behav Neurosci. 2020;14:57 pubmed publisher
immunohistochemistry; mouse; 1:200; loading ...; fig 6i	Lee J, Hong J, Yoon B, Son K, Lee K, Im D, et al. Expression of Cellular Receptors in the Ischemic Hemisphere of Mice with Increased Glucose Uptake. Exp Neurobiol. 2020;29:70-79 pubmed publisher
western blot; rat; fig 1	Ibáñez I, Díez Guerra F, Giménez C, Zafra F. Activity dependent internalization of the glutamate transporter GLT-1 mediated by ?-arrestin 1 and ubiquitination. Neuropharmacology. 2016;107:376-386 pubmed publisher
	Zoltowska K, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Sci Rep. 2018;8:8718 pubmed publisher
	Logan C, Lacrosse A, Knackstedt L. Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology. 2018;135:297-307 pubmed publisher
	Jolly S, Bazargani N, Quiroga A, Pringle N, Attwell D, Richardson W, et al. G protein-coupled receptor 37-like 1 modulates astrocyte glutamate transporters and neuronal NMDA receptors and is neuroprotective in ischemia. Glia. 2018;66:47-61 pubmed publisher
	Chai H, Diaz Castro B, Shigetomi E, Monte E, Octeau J, Yu X, et al. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence. Neuron. 2017;95:531-549.e9 pubmed publisher
	Batiuk M, de Vin F, Duque S, Li C, Saito T, Saido T, et al. An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody. J Biol Chem. 2017;292:8874-8891 pubmed publisher
	Rosenblum L, Shamamandri Markandaiah S, Ghosh B, Foran E, Lepore A, Pasinelli P, et al. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Exp Neurol. 2017;292:145-153 pubmed publisher
	Andrés Benito P, Moreno J, Aso E, Povedano M, Ferrer I. Amyotrophic lateral sclerosis, gene deregulation in the anterior horn of the spinal cord and frontal cortex area 8: implications in frontotemporal lobar degeneration. Aging (Albany NY). 2017;9:823-851 pubmed publisher
	Talman W, Dragon D, Lin L. Reduced responses to glutamate receptor agonists follow loss of astrocytes and astroglial glutamate markers in the nucleus tractus solitarii. Physiol Rep. 2017;5: pubmed publisher
	Miller A, Shah A, Aperi B, Kurpad S, Stemper B, Glavaski Joksimovic A. Acute death of astrocytes in blast-exposed rat organotypic hippocampal slice cultures. PLoS ONE. 2017;12:e0173167 pubmed publisher
	Dooves S, Bugiani M, Postma N, Polder E, Land N, Horan S, et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J Clin Invest. 2016;126:1512-24 pubmed publisher

product information

Catalog Number :

AB1783

Subcategory :

Neuroscience

Product Name :

Anti-Glutamate Transporter Antibody, Glial

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P43004

Host Name :

Guinea Pig

Antigen :

Glutamate Transporter

Conjugate :

Serum

Product Description :

Anti-Glutamate Transporter Antibody, Glial

Cross Reactivity :

Human;Mouse;Rat

Background :

Glutamate transporters (GluT) function to remove L-glutamate (Glu), the primary excitatory neurotransmitter in the mammalian central nervous system (CNS), from the synaptic cleft. By clearing the synapse in this manner Glu can be recycled for later use, the proper diffusion gradient can be maintained and excitotoxicity can be prevented. There have been reports of many different members of a GluT multigene family; GLT1, GLAST, EAAC1 and EAAT2. mRNA has been identified in brain for each of these proteins. EAAT2 transports L-glutamate and also L- and D-aspartate. It is essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

ALT Names :

GLT-1, EAAT2

Immunogen :

Synthetic peptide from the carboxy-terminus of rat GLT-1.

Specificity :

Glial Glutamate Transporter GLT-1 (EAAT2). The antibody has been tested on central nervous system tissue. Preabsorption of the antiserum with the immunogen peptide (Catalog number AG391) completely abolishes the immunostaining.

Package Size :

50 µL

Uses :

Immunohistochemistry (Paraffin);Immunofluorescence;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.