DFF45/35 Antibody, NT | EMD Millipore AB16961 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DFF45/35 Antibody, NT

catalog :

AB16961

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

product information

Catalog Number :

AB16961

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-DFF45/35 Antibody, NT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O00273

Host Name :

Rabbit

Antigen :

DFF45/35

Conjugate :

Purified

Product Description :

Anti-DFF45/35 Antibody, NT

Cross Reactivity :

Human

Immunogen :

Polyclonal antibody raised against a peptide corresponding to amino acids 2-21 at N-terminus of human DFF (Liu et al. 1997).

Specificity :

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. A human DNA fragmentation factor (DFF) was identified recently which was cleaved by caspase-3 during apoptosis (Liu et al. 1997). Mouse homologue of human DFF was identified as a DNase inhibitor designated ICAD (Enari et al. 1998; Sakahira et al. 1998). Upon cleavage of DFF/ICAD, a caspase activated deoxyribonuclease (CAD) is released and activated and eventually causes the degradation of DNA in the nuclei (Enari et al. 1998; Sakahira et al. 1998). Therefore, the cleavage of CAD inhibitor molecule DFF/ICAD, which cause DNase activation and DNA degradation, is the hallmark of apoptotic cell death (Wylile et al. 1998).

Package Size :

100 µg

Uses :

Immunoprecipitation;Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.