Apaf-1 Antibody, NT | EMD Millipore AB16941 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Apaf-1 Antibody, NT

catalog :

AB16941

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

AB16941

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Apaf-1 Antibody, NT

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

O14727

Host Name :

Rabbit

Antigen :

Apaf-1

Conjugate :

Purified

Product Description :

Anti-Apaf-1 Antibody, NT

Cross Reactivity :

Human;Mouse

ALT Names :

Apoptosis Protease-activating Factor 1

Immunogen :

Polyclonal antibody raised against a peptide corresponding to amino acids 12 to 28 of human Apaf1 (Zou et al. 1997) The sequences of the immunogenic peptide are identical between human and mouse (Zou et al. 1997; Cecconi et al. 1998).

Specificity :

Apoptosis is related to many diseases and is induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and was designated Apaf1 for apoptosis protease-activating factor 1(Zou et al. 1997; Cecconi et al. 1998). Apaf1 binds to cytochrome C (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 which is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis (Li et al. 1997). Apaf1 can also associate with caspase-4 and caspase-8 (Hu et al. 1998). Apaf1 is ubiquitously expressed in human tissues (Zou et al. 1997).

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Maintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.