Dopamine Transporter Antibody | EMD Millipore AB1591P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Dopamine Transporter Antibody

catalog :

AB1591P

quantity :

50 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; fig 2e	Liu C, Kershberg L, Wang J, Schneeberger S, Kaeser P. Dopamine Secretion Is Mediated by Sparse Active Zone-like Release Sites. Cell. 2018;172:706-718.e15 pubmed publisher
western blot; rat; loading ...; fig 5b	ConceiÃ§Ã£o E, Carvalho J, ManhÃ£es A, Guarda D, Figueiredo M, Quitete F, et al. Effect of Early Overfeeding on Palatable Food Preference and Brain Dopaminergic Reward System at Adulthood: Role of Calcium Supplementation. J Neuroendocrinol. 2016;28: pubmed publisher
	Huang J, Yang G, Li Z, Leung C, Wang W, Li Y, et al. Involvement of dopamine D3 receptor and dopamine transporter in methamphetamine-induced behavioral sensitization in tree shrews. Brain Behav. 2020;10:e01533 pubmed publisher
	Hammond S, Popichak K, Li X, Hunt L, Richman E, Damale P, et al. The Nurr1 Ligand,1,1-bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane, Modulates Glial Reactivity and Is Neuroprotective in MPTP-Induced Parkinsonism. J Pharmacol Exp Ther. 2018;365:636-651 pubmed publisher

product information

Catalog Number :

AB1591P

Subcategory :

Neuroscience

Product Name :

Anti-Dopamine Transporter Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q01959

Host Name :

Rabbit

Antigen :

Dopamine Transporter

Conjugate :

Affinity Purified

Product Description :

Anti-Dopamine Transporter Antibody

Cross Reactivity :

Mouse;Rat

Background :

Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm.

ALT Names :

DAT

Immunogen :

An 18 amino acid peptide sequence near the NH2-terminus of rat brain dopamine transporter coupled to KLH (Kilty et al. 1991; Giros et al. 1991; Shimada et al. 1991; Kitayma 1992). This region is presumably the cytoplasmic domain.

Specificity :

Recognizes Dopamine transporter (DAT). By Western blot the antibody recognizes a broad 80 kDa band in rat striatum (Lew et al. 1992; Freed et al. 1995; Vaughan et al. 1996) and not cerebellum. Rat DAT contains various carbohydrate moieties and neuraminidase and N-Glycanase treatment reduces its molecular weight to about 55 kDa.

Package Size :

50 μg

Uses :

ELISA;Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.