NMDAR2B Antibody | EMD Millipore AB1557P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NMDAR2B Antibody

catalog :

AB1557P

quantity :

10 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:1000; loading ...; fig 6b	Shepard A, Scheffel J, Yu W. Relationships between neuronal birthdates and tonotopic positions in the mouse cochlear nucleus. J Comp Neurol. 2019;527:999-1011 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 3a	Kim J, Ko A, Hyun H, Min S, Kim J. PDI regulates seizure activity via NMDA receptor redox in rats. Sci Rep. 2017;7:42491 pubmed publisher
	Sutton L, Orlandi C, Song C, Oh W, Muntean B, Xie K, et al. Orphan receptor GPR158 controls stress-induced depression. elife. 2018;7: pubmed publisher
	Favuzzi E, Marques Smith A, Deogracias R, Winterflood C, Sánchez Aguilera A, Mantoan L, et al. Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron. 2017;95:639-655.e10 pubmed publisher
	Huang T, Hsueh Y. Calcium/calmodulin-dependent serine protein kinase (CASK), a protein implicated in mental retardation and autism-spectrum disorders, interacts with T-Brain-1 (TBR1) to control extinction of associative memory in male mice. J Psychiatry Neurosci. 2017;42:37-47 pubmed
	Barad Z, Grattan D, Leitch B. NMDA Receptor Expression in the Thalamus of the Stargazer Model of Absence Epilepsy. Sci Rep. 2017;7:42926 pubmed publisher
	Calvo Rodríguez M, de la Fuente C, García Durillo M, Garcia Rodriguez C, Villalobos C, Núñez L. Aging and amyloid ? oligomers enhance TLR4 expression, LPS-induced Ca2+ responses, and neuron cell death in cultured rat hippocampal neurons. J Neuroinflammation. 2017;14:24 pubmed publisher

product information

Catalog Number :

AB1557P

Subcategory :

Neuroscience

Product Name :

Anti-NMDAR2B Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q13224

Host Name :

Rabbit

Antigen :

NMDAR2B

Conjugate :

Purified

Product Description :

Anti-NMDAR2B Antibody

Cross Reactivity :

Human;Mouse;Rat

Background :

NMDA receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long term potentiation, an activity dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). GRIN2B may be a candidate gene for the neurodegenerative disorder dentato-rubro-pallidoluysian atrophy (DRPLA). Properties of NMDAR include modulation by glycine, inhibition by Zn2+, voltage dependent Mg2+ blockade and high Ca2+ permeability. The involvement of NMDAR in the CNS has become a focus area for neurodegenerative diseases such as Alzheimer's disease and also epilepsy and ischemic neuronal cell death.

ALT Names :

N-methyl D-aspartate receptor subtype 2B;N-methyl-D-aspartate receptor subunit 2B;N-methyl-D-aspartate receptor subunit 3;glutamate receptor subunit epsilon-2;glutamate receptor, ionotropic, N-methyl D-aspartate 2B;Glutamate

Immunogen :

C-Terminal Fusion Protein of the NMDAR2B (30 kDa).

Specificity :

NMDAR2B. Strong and specific immunolabeling of the 180 kDa NMDAR2B subunit of the NMDA receptor. No reactivity to NMDAR2A or NMDAR2C by Western blot. Immunolabeling has been blocked by preadsorption of the antibody with the C-terminal fusion protein that was used to generate the antibody.

Package Size :

10 μg

Uses :

Immunohistochemistry;Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.