Synapsin I Antibody | EMD Millipore AB1543P product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Synapsin I Antibody

catalog :

AB1543P

quantity :

10 μg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 5b	Schaffer T, Smith J, Cook E, Phan T, Margolis S. PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5. Cell Rep. 2018;25:2470-2483.e8 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 3u	Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlen M, et al. Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell. 2018;173:153-165.e22 pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig s8d	Vainchtein I, Chin G, Cho F, Kelley K, Miller J, Chien E, et al. Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development. Science. 2018;359:1269-1273 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 4c	Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed publisher
western blot; rat; loading ...; fig 5a	Latina V, Caioli S, Zona C, Ciotti M, Amadoro G, Calissano P. Impaired NGF/TrkA Signaling Causes Early AD-Linked Presynaptic Dysfunction in Cholinergic Primary Neurons. Front Cell Neurosci. 2017;11:68 pubmed publisher
western blot; mouse; 1:500; loading ...; fig 3a	Dengler Crish C, Smith M, Wilson G. Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease. J Alzheimers Dis. 2017;55:1605-1619 pubmed publisher
western blot; mouse; loading ...; fig 7a	Fukada M, Nakayama A, Mamiya T, Yao T, Kawaguchi Y. Dopaminergic abnormalities in Hdac6-deficient mice. Neuropharmacology. 2016;110:470-479 pubmed publisher
immunocytochemistry; human; 1:500; loading ...; fig 1h	Chailangkarn T, Trujillo C, Freitas B, Hrvoj Mihic B, Herai R, Yu D, et al. A human neurodevelopmental model for Williams syndrome. Nature. 2016;536:338-43 pubmed
western blot; human; fig 5	Kurbatskaya K, Phillips E, Croft C, Dentoni G, Hughes M, Wade M, et al. Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer's disease brain. Acta Neuropathol Commun. 2016;4:34 pubmed publisher
	Velasco C, Llobet A. Synapse elimination activates a coordinated homeostatic presynaptic response in an autaptic circuit. Commun Biol. 2020;3:260 pubmed publisher
	Zhang P, Lu H, Peixoto R, Pines M, Ge Y, Oku S, et al. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships. Cell. 2018;174:1450-1464.e23 pubmed publisher
	Koeppen J, Nguyen A, Nikolakopoulou A, Garcia M, Hanna S, Woodruff S, et al. Functional Consequences of Synapse Remodeling Following Astrocyte-Specific Regulation of Ephrin-B1 in the Adult Hippocampus. J Neurosci. 2018;38:5710-5726 pubmed publisher
	Yamagata M, Duan X, Sanes J. Cadherins Interact With Synaptic Organizers to Promote Synaptic Differentiation. Front Mol Neurosci. 2018;11:142 pubmed publisher
	Wang Z, Jackson R, Hong W, Taylor W, Corbett G, Moreno A, et al. Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci. 2017;37:11947-11966 pubmed publisher
	Jackson R, Rudinskiy N, Herrmann A, Croft S, Kim J, Petrova V, et al. Human tau increases amyloid ? plaque size but not amyloid ?-mediated synapse loss in a novel mouse model of Alzheimer's disease. Eur J Neurosci. 2016;44:3056-3066 pubmed publisher
	Li L, Tasic B, Micheva K, Ivanov V, Spletter M, Smith S, et al. Visualizing the distribution of synapses from individual neurons in the mouse brain. PLoS ONE. 2010;5:e11503 pubmed publisher

product information

Catalog Number :

AB1543P

Subcategory :

Neuroscience

Product Name :

Anti-Synapsin I Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P17600

Host Name :

Rabbit

Antigen :

Synapsin I

Conjugate :

Purified

Product Description :

Anti-Synapsin I Antibody

Cross Reactivity :

Bovine;Human;Mouse;Rat

Background :

The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time. Synapsins are encoded by three different genes, synapsin I, II and III, and different neuron terminals will encode different amounts of these; synapsin will make up 1% of total brain protein at any one time. Current studies suggest the following hypothesis for the role of synapsin: synapsins bind synaptic vesicles to components of the cytoskeleton which prevents them from migrating to the presynaptic membrane and releasing transmitter. During an action potential, synapsins are phosphorylated by Ca2+/calmodulin-dependent protein kinase II, releasing the synaptic vesicles and allowing them to move to the membrane and release their neurotransmitter.

ALT Names :

Synapsin-1

Immunogen :

Synapsin I (mixture of Ia & Ib) purified from bovine brain.

Specificity :

Synapsin I (Mr of 80,000 and 77,000). Synapsin is located only in brain nerve terminal and is an excellent marker for synapes. Immunolabeling is blocked by preadsorption of the antibody with synapsin I.

Package Size :

10 μg

Uses :

ELISA;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Immunoprecipitation;Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt.