Tyrosine Hydroxylase Antibody | EMD Millipore AB1542 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tyrosine Hydroxylase Antibody

catalog :

AB1542

quantity :

100 µL

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse, domestic rabbit

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section

citations: 38

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 1c	Ito H, Sales A, Fry C, Kanai A, Drake M, Pickering A. Probabilistic, spinally-gated control of bladder pressure and autonomous micturition by Barrington's nucleus CRH neurons. elife. 2020;9: pubmed publisher
immunohistochemistry; mouse; 1:150-1:300; loading ...; fig 3b	Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, et al. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020;577:676-681 pubmed publisher
immunohistochemistry; mouse; 1:1000; loading ...; fig 3i	Popova D, Desai N, Blendy J, Pang Z. Synaptic regulation by OPRM1 variants in reward neurocircuitry. J Neurosci. 2019;: pubmed publisher
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 5b	Zeng X, Ye M, Resch J, Jedrychowski M, Hu B, Lowell B, et al. Innervation of thermogenic adipose tissue via a calsyntenin 3β-S100b axis. Nature. 2019;569:229-235 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 7a	Poltavski D, Colombier P, Hu J, Duron A, Black B, Makita T. Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin. elife. 2019;8: pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig s8h	Paul A, Chaker Z, Doetsch F. Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science. 2017;356:1383-1386 pubmed publisher
immunocytochemistry; human; 1:1000; loading ...; fig 1f	Cha Y, Han M, Cha H, Zoldan J, Burkart A, Jung J, et al. Metabolic control of primed human pluripotent stem cell fate and function by the miR-200c-SIRT2 axis. Nat Cell Biol. 2017;19:445-456 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1a	Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, et al. Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech. 2017;10:633-643 pubmed publisher
immunohistochemistry; mouse; 1:3000; loading ...; fig 2b	Wang J, O Sullivan M, Mukherjee D, Punal V, Farsiu S, Kay J. Anatomy and spatial organization of Müller glia in mouse retina. J Comp Neurol. 2017;525:1759-1777 pubmed publisher
immunocytochemistry; mouse; 1:100; loading ...; fig s23b	Ho Y, Zhou L, Tam K, Too H. Enhanced non-viral gene delivery by coordinated endosomal release and inhibition of β-tubulin deactylase. Nucleic Acids Res. 2017;45:e38 pubmed publisher
immunohistochemistry; mouse; 1:800; fig 8	Carnevale D, Perrotta M, Pallante F, Fardella V, Iacobucci R, Fardella S, et al. A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication. Nat Commun. 2016;7:13035 pubmed publisher
immunocytochemistry; domestic rabbit; 1:800; loading ...; fig 3	Inokaitis H, Pauziene N, Rysevaite Kyguoliene K, Pauza D. Innervation of sinoatrial nodal cells in the rabbit. Ann Anat. 2016;205:113-21 pubmed publisher
immunocytochemistry; mouse; 1:1000; fig 2 immunohistochemistry; mouse; 1:1000; fig 1	Srinivasan R, Henley B, Henderson B, Indersmitten T, Cohen B, Kim C, et al. Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons. J Neurosci. 2016;36:65-79 pubmed publisher
immunohistochemistry - free floating section; mouse; 1:1000; fig 11	Geerling J, Kim M, Mahoney C, Abbott S, Agostinelli L, Garfield A, et al. Genetic identity of thermosensory relay neurons in the lateral parabrachial nucleus. Am J Physiol Regul Integr Comp Physiol. 2016;310:R41-54 pubmed publisher
	Lavin T, Jin L, Lea N, Wickersham I. Monosynaptic Tracing Success Depends Critically on Helper Virus Concentrations. Front Synaptic Neurosci. 2020;12:6 pubmed publisher
	Yan Y, Beckley N, Kim V, Drenan R. Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits. Eneuro. 2019;6: pubmed publisher
	Paixão S, Loschek L, Gaitanos L, Alcalà Morales P, Goulding M, Klein R. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements. Neuron. 2019;104:749-764.e6 pubmed publisher
	Berger J, Singh P, Khrimian L, Morgan D, Chowdhury S, Arteaga Solis E, et al. Mediation of the Acute Stress Response by the Skeleton. Cell Metab. 2019;30:890-902.e8 pubmed publisher
	Miyamoto Y, Nagayoshi I, Nishi A, Fukuda T. Three divisions of the mouse caudal striatum differ in the proportions of dopamine D1 and D2 receptor-expressing cells, distribution of dopaminergic axons, and composition of cholinergic and GABAergic interneurons. Brain Struct Funct. 2019;224:2703-2716 pubmed publisher
	Rajendran P, Challis R, Fowlkes C, Hanna P, Tompkins J, Jordan M, et al. Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies. Nat Commun. 2019;10:1944 pubmed publisher
	Pristerá A, Blomeley C, Lopes E, Threlfell S, Merlini E, Burdakov D, et al. Dopamine neuron-derived IGF-1 controls dopamine neuron firing, skill learning, and exploration. Proc Natl Acad Sci U S A. 2019;116:3817-3826 pubmed publisher
	Pérez Fernández V, Milosavljevic N, Allen A, Vessey K, Jobling A, Fletcher E, et al. Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina. Curr Biol. 2019;: pubmed publisher
	McWilliams T, Barini E, Pohjolan Pirhonen R, Brooks S, Singh F, Burel S, et al. Phosphorylation of Parkin at serine 65 is essential for its activation in vivo. Open Biol. 2018;8: pubmed publisher
	Kremer M, Yalcin I, Goumon Y, Wurtz X, Nexon L, Daniel D, et al. A Dual Noradrenergic Mechanism for the Relief of Neuropathic Allodynia by the Antidepressant Drugs Duloxetine and Amitriptyline. J Neurosci. 2018;38:9934-9954 pubmed publisher
	Sharma S, Kim L, Mayr K, Elliott D, Whelan P. Parallel descending dopaminergic connectivity of A13 cells to the brainstem locomotor centers. Sci Rep. 2018;8:7972 pubmed publisher
	Henrich M, Geibl F, Lee B, Chiu W, Koprich J, Brotchie J, et al. A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta Neuropathol Commun. 2018;6:39 pubmed publisher
	Dawes J, Weir G, Middleton S, Patel R, Chisholm K, Pettingill P, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron. 2018;97:806-822.e10 pubmed publisher
	McWilliams T, Prescott A, Montava Garriga L, Ball G, Singh F, Barini E, et al. Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand. Cell Metab. 2018;27:439-449.e5 pubmed publisher
	Burnham N, Thiele T. Voluntary Binge-like Ethanol Consumption Site-specifically Increases c-Fos Immunoexpression in Male C57BL6/J Mice. Neuroscience. 2017;367:159-168 pubmed publisher
	Ruiz de Azua I, Mancini G, Srivastava R, Rey A, Cardinal P, Tedesco L, et al. Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest. 2017;127:4148-4162 pubmed publisher
	McWilliams T, Howard L, Wyatt S, Davies A. TNF superfamily member APRIL enhances midbrain dopaminergic axon growth and contributes to the nigrostriatal projection in vivo. Exp Neurol. 2017;298:97-103 pubmed publisher
	Gao L, Bonilla Henao V, García Flores P, Arias Mayenco I, Ortega Saenz P, Lopez Barneo J. Gene expression analyses reveal metabolic specifications in acute O2 -sensing chemoreceptor cells. J Physiol. 2017;595:6091-6120 pubmed publisher
	García González D, Khodosevich K, Watanabe Y, Rollenhagen A, Lübke J, Monyer H. Serotonergic Projections Govern Postnatal Neuroblast Migration. Neuron. 2017;94:534-549.e9 pubmed publisher
	Mesman S, van Hooft J, Smidt M. Mest/Peg1 Is Essential for the Development and Maintenance of a SNc Neuronal Subset. Front Mol Neurosci. 2016;9:166 pubmed publisher
	Doucet Beaupré H, Gilbert C, Profes M, Chabrat A, Pacelli C, Giguère N, et al. Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons. Proc Natl Acad Sci U S A. 2016;113:E4387-96 pubmed publisher
	Bandrowski A, Brush M, Grethe J, Haendel M, Kennedy D, Hill S, et al. The Resource Identification Initiative: a cultural shift in publishing. Brain Behav. 2016;6:e00417 pubmed publisher
	Lelos M, Morgan R, Kelly C, Torres E, Rosser A, Dunnett S. Amelioration of non-motor dysfunctions after transplantation of human dopamine neurons in a model of Parkinson's disease. Exp Neurol. 2016;278:54-61 pubmed publisher
	Root D, Hoffman A, Good C, Zhang S, Gigante E, Lupica C, et al. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. J Neurosci. 2015;35:3460-9 pubmed publisher

product information

Catalog Number :

AB1542

Subcategory :

Neuroscience

Product Name :

Anti-Tyrosine Hydroxylase Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P07101

Host Name :

Sheep

Antigen :

Tyrosine Hydroxylase

Conjugate :

Affinity Purified

Product Description :

Anti-Tyrosine Hydroxylase Antibody

Cross Reactivity :

Mammals;Rat;Mouse

Background :

Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.

ALT Names :

Tyrosine 3-hydroxylase;Tyrosine 3-hydroxylase;tyrosine hydroxylase

Immunogen :

Native tyrosine hydroxylase from rat pheochromocytoma (J. Biol. Chem.,1982, 257:9416-9423).

Specificity :

Tyrosine Hydroxylase (TH, Tyrosine Monooxygenase). Cross-reacts with all mammalian forms tested to date and some non-mammalian forms.

Package Size :

100 µL

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 6 months at -20 to -80°C in undiluted aliquots from date of receipt. Store in a NON-self-defrosting freezer. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.