Peripherin Antibody | EMD Millipore AB1530 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Peripherin Antibody

catalog :

AB1530

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

African green monkey, common marmoset, mouse, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 14

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:1000; fig 4c	Xiao D, Liu X, Zhang M, Zou M, Deng Q, Sun D, et al. Direct reprogramming of fibroblasts into neural stem cells by single non-neural progenitor transcription factor Ptf1a. Nat Commun. 2018;9:2865 pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig s6e	Furlan A, Dyachuk V, Kastriti M, Calvo Enrique L, Abdo H, Hadjab S, et al. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science. 2017;357: pubmed publisher
immunohistochemistry - frozen section; mouse; 1:800; fig s5	Nakashima H, Ohkawara B, Ishigaki S, Fukudome T, Ito K, Tsushima M, et al. R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5. Sci Rep. 2016;6:28512 pubmed publisher
immunohistochemistry - frozen section; common marmoset; 1:100; fig 1	Hosoya M, Fujioka M, Kobayashi R, Okano H, Ogawa K. Overlapping expression of anion exchangers in the cochlea of a non-human primate suggests functional compensation. Neurosci Res. 2016;110:1-10 pubmed publisher
immunohistochemistry; mouse; 1:500; loading ...; fig 5e	Lippoldt E, Ongun S, Kusaka G, McKemy D. Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFR?3. Proc Natl Acad Sci U S A. 2016;113:4506-11 pubmed publisher
immunohistochemistry; African green monkey; 1:100; fig 1i	Hosoya M, Fujioka M, Ogawa K, Okano H. Distinct Expression Patterns Of Causative Genes Responsible For Hereditary Progressive Hearing Loss In Non-Human Primate Cochlea. Sci Rep. 2016;6:22250 pubmed publisher
	Rossor A, Sleigh J, Groves M, Muntoni F, Reilly M, Hoogenraad C, et al. Loss of BICD2 in muscle drives motor neuron loss in a developmental form of spinal muscular atrophy. Acta Neuropathol Commun. 2020;8:34 pubmed publisher
	Ceriani F, Hendry A, Jeng J, Johnson S, Stephani F, Olt J, et al. Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells. EMBO J. 2019;38: pubmed publisher
	Geisler S, Huang S, Strickland A, Doan R, Summers D, Mao X, et al. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. J Exp Med. 2019;216:294-303 pubmed publisher
	Shorrock H, van der Hoorn D, Boyd P, Llavero Hurtado M, Lamont D, Wirth B, et al. UBA1/GARS-dependent pathways drive sensory-motor connectivity defects in spinal muscular atrophy. Brain. 2018;141:2878-2894 pubmed publisher
	Li J, Ito M, Ohkawara B, Masuda A, Ohno K. Differential effects of spinal motor neuron-derived and skeletal muscle-derived Rspo2 on acetylcholine receptor clustering at the neuromuscular junction. Sci Rep. 2018;8:13577 pubmed publisher
	Ito K, Ohkawara B, Yagi H, Nakashima H, Tsushima M, Ota K, et al. Lack of Fgf18 causes abnormal clustering of motor nerve terminals at the neuromuscular junction with reduced acetylcholine receptor clusters. Sci Rep. 2018;8:434 pubmed publisher
	Yonekubo S, Tatemichi S, Maruyama K, Kobayashi M. Alpha1A-adrenoceptor antagonist improves underactive bladder associated with diabetic cystopathy via bladder blood flow in rats. BMC Urol. 2017;17:64 pubmed publisher
	Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, et al. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017;12:8 pubmed publisher

product information

Catalog Number :

AB1530

Subcategory :

Neuroscience

Product Name :

Anti-Peripherin Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P41219

Host Name :

Rabbit

Antigen :

Peripherin

Conjugate :

Serum

Product Description :

Anti-Peripherin Antibody

Cross Reactivity :

Human;Rat;Mouse;Bovine;Pig

Background :

Peripherin is a 56-58 kDa type III intermediate filament protein (Portier et al. 1983), expressed in motor, sensory and sympathetic system neurons as well as neuroendocrine skin carcinomas and certain melanocytic tumors. It is often used an indicator of enteric ganglion cell density in normal and diseased (e.g. Hirschsprung's disease) states. Abnormal inclusions containing peripherin have also been reported in ALS. During normal, late neurogenesis peripherin appears after the expression of nestin, vimentin, alpha-internexin and neurofilaments and is involved in the differentiation of neurons, namely of the peripheral nervous system, and also probably in axonal regeneration. Peripherin is not related to peripherin-RDS, a photoreceptor protein associated with retinal degeneration and blindness.

Immunogen :

Electrophoretically pure trp-E-peripherin fusion protein [Dev. Brain Res. (1990) 57:235-248], containing all but the 4 N terminal amino acids of rat peripherin. Fusion protein purified from bacterial inclusion bodies by DEAE-cellulose chromatography in 6 M urea followed by preparative SDS-PAGE.

Specificity :

Recognizes Peripherin. The antibody stains a ~57 kDa band cleanly and specifically and does not stain vimentin, GFAP, alpha-internexin or any of the neurofilament subunits. Strong staining on rat, mouse, human, pig and cow peripherin. Does not stain chicken, quail or other more distantly related species which appear to lack peripherin.

Package Size :

100 µL

Uses :

Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting

Storage :

Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.