Cytochrome P450 Enzyme CYP2E1 Antibody | EMD Millipore AB1252 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Cytochrome P450 Enzyme CYP2E1 Antibody

catalog :

AB1252

quantity :

100 µL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; fig 7f immunohistochemistry; mouse; loading ...; fig 2c	Choi W, Kim H, Kim M, Cinar R, Yi H, Eun H, et al. Glutamate Signaling in Hepatic Stellate Cells Drives Alcoholic Steatosis. Cell Metab. 2019;30:877-889.e7 pubmed publisher
western blot; mouse; loading ...; fig s2d	Yang A, Inamine T, Hochrath K, Chen P, Wang L, Llorente C, et al. Intestinal fungi contribute to development of alcoholic liver disease. J Clin Invest. 2017;127:2829-2841 pubmed publisher
immunohistochemistry - paraffin section; mouse; 1:750; fig 3	Shearn C, Orlicky D, McCullough R, Jiang H, Maclean K, Mercer K, et al. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS ONE. 2016;11:e0154152 pubmed publisher
western blot; mouse; fig 3	Park W, Kim S, Kim Y, Park J. Bortezomib alleviates drug-induced liver injury by regulating CYP2E1 gene transcription. Int J Mol Med. 2016;37:613-22 pubmed publisher
	Ganesan M, Tikhanovich I, Vangimalla S, Dagur R, Wang W, Poluektova L, et al. Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism. Cell Mol Gastroenterol Hepatol. 2018;5:101-112 pubmed publisher
	Wang P, Shehu A, Lu J, Joshi R, Venkataramanan R, Sugamori K, et al. Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver. Biochem Pharmacol. 2017;145:218-225 pubmed publisher

product information

Catalog Number :

AB1252

Subcategory :

Metabolism

Product Name :

Anti-Cytochrome P450 Enzyme CYP2E1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P05181

Host Name :

Rabbit

Antigen :

Cytochrome P450 Enzyme CYP2E1

Conjugate :

Serum

Product Description :

Anti-Cytochrome P450 Enzyme CYP2E1 Antibody

Cross Reactivity :

Human;Rat;Mouse

Background :

Cytochrome P450 (CYP) is a huge and diverse superfamily of hemoproteins. It metabolize the fatty acid arachadonic acid (AA) to regulators of vascular tone. Most CYPs can metabolize multiple substrates, and can catalyze multiple reactions. This accounts for their central importance in metabolizing the extremely large number of endogenous and exogenous molecules. In the liver, these substrates include drugs and toxic compounds as well as metabolic products such as bilirubin (a breakdown product of hemoglobin). Cytochrome P450 enzymes are present in many other tissues of the body including the mucosa of the gastrointestinal tract, and play important roles in hormone synthesis and breakdown (including estrogen and testosterone synthesis and metabolism), cholesterol synthesis, and vitamin D metabolism. More than 7700 distinct CYP sequences are known as of September 2007.

ALT Names :

cytochrome P450 2E1;cytochrome P450, family 2, subfamily E, polypeptide 1;cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1;flavoprotein-linked monooxygenase;microsomal monooxygenase;xenobiotic monooxygenase

Immunogen :

Synthetic peptide

Specificity :

Reacts with human and rat cytochrome P450 enzyme CYP2E1 in hepatic microsomal fractions. No cross-reactivity with other cytochrome P450 enzymes in these species.

Package Size :

100 µL

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at -20°C in undiluted aliquots from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.